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Table 2 Demographic characteristics associated with different esophageal lesions

From: Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional study

Demographic characteristics

HGIN/ESCC

LGIN

Esophagitis

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

OR

(95% CI)

P value

Adjusted OR a

(95% CI)

P value

Gender (Female)

0.54 (0.45–0.66)

< 0.001

–

–

0.74 (0.68–0.82)

< 0.001

–

–

0.80 (0.76–0.85)

< 0.001

–

–

Age, years

 40–49

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

 50–59

4.96 (3.12–8.40)

< 0.001

–

–

3.17 (2.65–3.81)

< 0.001

–

–

1.80 (1.65–1.96)

< 0.001

–

–

 60–69

15.73 (10.06–26.29)

< 0.001

–

–

7.18 (6.04–8.60)

< 0.001

–

–

2.84 (2.60–3.10)

< 0.001

–

–

Education (Formal)

0.73 (0.58–0.94)

0.013

–

–

0.68 (0.61–0.77)

< 0.001

–

–

0.93 (0.86–1.01)

0.097

–

–

Annual income per family (RMB)

 < 10,000

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

 10,000-

0.65 (0.49–0.89)

0.005

–

–

1.00 (0.86–1.18)

0.973

–

–

0.86 (0.78–0.95)

0.005

–

–

 30,000-

0.80 (0.61–1.07)

0.124

–

–

1.03 (0.88–1.20)

0.725

–

–

1.02 (0.93–1.13)

0.564

–

–

50,000-

0.60 (0.43–0.85)

0.004

–

–

0.82 (0.69–0.99)

0.033

–

–

0.87 (0.78–0.98)

0.018

–

–

≥70,000

0.42 (0.26–0.65)

< 0.001

–

–

0.58 (0.46–0.73)

< 0.001

–

–

0.90 (0.79–1.02)

0.106

–

–

BMI

 18.5 to 23.9

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

1.00 (reference)

–

–

–

 < 18.5

1.69 (0.97–2.73)

0.044

–

–

0.95 (0.67–1.32)

0.791

–

–

1.02 (0.82–1.26)

0.878

–

–

 24.0 to 27.9

0.80 (0.65–0.98)

0.029

–

–

0.93 (0.84–1.03)

0.166

–

–

0.97 (0.91–1.04)

0.379

–

–

 ≥ 28.0

0.55 (0.37–0.78)

0.001

–

–

0.76 (0.64–0.89)

0.001

–

–

0.78 (0.70–0.86)

< 0.001

–

–

Family history of cancer

1.50 (1.23–1.82)

< 0.001

1.64 (1.34–2.00)

< 0.001

1.24 (1.12–1.37)

< 0.001

1.33 (1.20–1.47)

< 0.001

1.19 (1.11–1.27)

< 0.001

1.22 (1.14–1.30)

< 0.001

History of chronic hepatitis and cirrhosis

1.96 (1.07–3.28)

0.018

1.91 (1.03–3.22)

0.025

1.36 (0.96–1.86)

0.067

1.36 (0.96–1.87)

0.070

3.05 (2.60–3.57)

< 0.001

2.96 (2.52–3.47)

< 0.001

  1. Source: WHO tumor histological classification 2000
  2. BMI body mass index (kg/m2), LGIN low-grade intraepithelial neoplasia, HGIN high-grade intraepithelial neoplasia, ESCC esophageal squamous cell carcinoma
  3. aadjusted for age, gender, education, BMI and income