Evaluating the effect of Neoadjuvant chemotherapy for esophageal Cancer using the RECIST system with shorter-axis measurements: a retrospective multicenter study

Table 2 Logistic regression analysis for estimating pathologically ineffective response (TRG 0–1a)

Characteristic	Univariate analysis		Multivariate analysis
Characteristic	Odds ratio (95% CI)	P-value	Odds ratio (95% CI)	P-value
RECIST classification by longest diameter		< 0.001		0.888
PR (vs. SD + PD)	0.36 (0.23–0.59)		0.95 (0.43–2.32)
RECIST classification by shorter axis		< 0.001		0.022
PR (vs. SD + PD)	0.24 (0.15–0.39)		0.43 (0.20–0.88)
^aMultiplication of longest diameter by shorter axis		< 0.001		0.112
PR (vs. SD + PD)	0.25 (0.15–0.40)		0.45 (0.17–1.21)

^aThe cut-off value of PR and SD + PD in the multiplication of the longest diameter and the shorter axis was defined as 51%, which was calculated by multiplication of 30% reduction rate in both axes
Abbreviations: CI confidence interval, PD progressive disease, PR partial response, RECIST Response Evaluation Criteria in Solid Tumors, SD stable disease, TRG tumor regression grade

ISSN: 1471-2407