Table 3 The inheritance model analysis of the ten SNPs in miRNA genes among Control and CIN groups
SNPs | Models | Genotypes | CIN n (%) | CON n (%) | OR (95% CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
rs1292037 | Codominant | T/T | 138 (31.7) | 329 (33.0) | 1.00 | 0.003 | 1753.7 | 1769.5 |
|  | T/C | 237 (54.5) | 465 (46.6) | 0.82 (0.64–1.06) |  |  |  | |
|  | C/C | 60 (13.8) | 204 (20.4) | 1.43 (1.01–2.02) |  |  |  | |
Dominant | T/T | 138 (31.7) | 329 (33.0) | 1.00 | 0.640 | 1763.1 | 1773.6 | |
|  | T/C-C/C | 297 (68.3) | 669 (67.0) | 0.94 (0.74–1.20) |  |  |  | |
Recessive | T/T-T/C | 375 (86.2) | 794 (79.6) | 1.00 | 0.002 | 1754.0 | 1764.5 | |
|  | C/C | 60 (13.8) | 204 (20.4) | 1.61 (1.17–2.20) |  |  |  | |
Overdominant | T/T-C/C | 198 (45.5) | 533 (53.4) | 1.00 | 0.006 | 1755.7 | 1766.3 | |
|  | T/C | 237 (54.5) | 465 (46.6) | 0.73 (0.58–0.91) |  |  |  | |
Log-additive | – | – | – | 1.12 (0.95–1.31) | 0.180 | 1761.5 | 1772.0 | |
rs13137 | Codominant | A/A | 138 (31.7) | 327 (32.8) | 1.00 | 0.005 | 1754.7 | 1770.5 |
|  | A/T | 236 (54.2) | 467 (46.8) | 0.84 (0.65–1.08) |  |  |  | |
|  | T/T | 61 (14.0) | 204 (20.4) | 1.41 (1.00–2.00) |  |  |  | |
Dominant | A/A | 138 (31.7) | 327 (32.8) | 1.00 | 0.700 | 1763.1 | 1773.7 | |
|  | A/T-T/T | 297 (68.3) | 671 (67.2) | 0.95 (0.75–1.21) |  |  |  | |
Recessive | A/A-A/T | 374 (86.0) | 794 (79.6) | 1.00 | 0.003 | 1754.7 | 1765.2 | |
|  | T/T | 61 (14.0) | 204 (20.4) | 1.58 (1.15–2.15) |  |  |  | |
Overdominant | A/A-T/T | 199 (45.8) | 531 (53.2) | 1.00 | 0.009 | 1756.5 | 1767.1 | |
|  | A/T | 236 (54.2) | 467 (46.8) | 0.74 (0.59–0.93) |  |  |  | |
Log-additive | – | – | – | 1.12 (0.95–1.31) | 0.180 | 1761.5 | 1772.0 | |
rs2745709 | Codominant | C/C | 129 (29.7) | 381 (38.2) | 1.00 | 0.001 | 1751.6 | 1767.5 |
|  | C/T | 249 (57.2) | 467 (46.8) | 0.64 (0.49–0.82) |  |  |  | |
|  | T/T | 57 (13.1) | 150 (15.0) | 0.89 (0.62–1.28) |  |  |  | |
Dominant | C/C | 129 (29.7) | 381 (38.2) | 1.00 | 0.002 | 1753.5 | 1764.1 | |
|  | C/T-T/T | 306 (70.3) | 617 (61.8) | 0.68 (0.54–0.87) |  |  |  | |
Recessive | C/C-C/T | 378 (86.9) | 848 (85.0) | 1.00 | 0.340 | 1762.4 | 1772.9 | |
|  | T/T | 57 (13.1) | 150 (15.0) | 1.17 (0.84–1.63) |  |  |  | |
Overdominant | C/C-T/T | 186 (42.8) | 531 (53.2) | 1.00 | < 0.001 | 1750.0 | 1760.6 | |
|  | C/T | 249 (57.2) | 467 (46.8) | 0.66 (0.52–0.82) |  |  |  | |
Log-additive | – | – | – | 0.87 (0.73–1.02) | 0.090 | 1760.4 | 1770.9 |