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Table 2 The allele and genotype distribution of the SNPs in control, CIN and cervical cancer groups

From: Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer

SNPs

Alleles/Genotypes

Control (n = 998)

CIN (n = 435)

CC (n = 743)

CIN vs Control

CC vs Control

CC vs CIN

n (%)

n (%)

n (%)

P value

OR(95%CI)

P value

OR(95%CI)

P value

OR(95%CI)

rs1292037

T

1123 (56.3)

513 (59.0)

875 (58.9)

0.179

0.90 [0.76–1.05]

0.122

0.90 [0.78–1.43]

0.969

1.00 [0.85–1.19]

C

873 (43.7)

357 (41.0)

611 (41.1)

      

T/T

329 (33.0)

138 (31.7)

268 (36.1)

0.004

 

0.320

 

0.010

 

T/C

465 (46.6)

237 (54.5)

339 (45.6)

      

C/C

204 (20.4)

60 (13.8)

136 (18.3)

      

rs13137

A

1121 (56.2)

512 (58.9)

874 (58.8)

0.181

1.12 [0.95–1.31]

0.117

1.11 [0.97–1.28]

0.987

1.00 [0.84–1.18]

T

875 (43.8)

358 (41.1)

612 (41.2)

      

A/A

327 (32.8)

138 (31.7)

268 (36.1)

0.006

 

0.303

 

0.011

 

A/T

467 (46.8)

236 (54.3)

338 (45.5)

      

T/T

204 (20.4)

61 (14.0)

137 (18.4)

      

rs2858061

G

1578 (79.1)

691 (79.4)

1149 (77.3)

0.824

0.98 [0.80–1.19]

0.219

1.11 [0.94–1.30]

0.233

1.13 [0.92–1.39]

C

418 (20.9)

179 (20.6)

337 (22.7)

      

G/G

628 (62.9)

271 (62.3)

450 (60.6)

0.436

 

0.453

 

0.171

 

G/C

322 (32.3)

149 (34.3)

249 (33.5)

      

C/C

48 (4.8)

15 (3.4)

44 (5.9)

      

rs34678647

G

1615 (80.9)

684 (78.6)

1207 (81.2)

0.157

0.87 [0.71–1.06]

0.816

1.02 [0.86–1.21]

0.125

1.18 [0.96–1.45]

T

381 (19.1)

186 (21.4)

279 (18.8)

      

G/G

662 (66.3)

263 (60.5)

490 (65.9)

0.020

 

0.509

 

0.125

 

G/T

291 (29.2)

158 (36.3)

227 (30.6)

      

T/T

45 (4.5)

14 (3.2)

26 (3.5)

      

rs2858060

C

1600 (80.2)

695 (79.9)

1162 (78.2)

0.865

0.98 [0.81–1.99]

0.157

0.89 [0.75–1.05]

0.333

0.90 [0.73–1.11]

G

396 (19.8)

175 (20.1)

324 (21.8)

      

C/C

642 (64.3)

274 (63.0)

455 (61.2)

0.603

 

0.369

 

0.397

 

C/G

316 (31.7)

147 (33.8)

252 (33.9)

      

G/G

40 (4.0)

14 (3.2)

36 (4.8)

      

rs2745709

C

1229 (61.6)

507 (58.3)

878 (59.1)

0.097

0.87 [0.74–1.03]

0.137

0.90 [0.79–1.03]

0.7

1.03 [0.87–1.22]

T

767 (38.4)

363 (41.7)

608 (40.9)

      

C/C

381 (38.2)

129 (29.7)

260 (35.0)

0.001

 

0.331

 

0.010

 

C/T

467 (46.8)

249 (57.2)

358 (48.2)

      

T/T

150 (15.0)

57 (13.1)

125 (16.8)

      

rs2297537

C

1618 (81.1)

729 (83.8)

1172 (78.9)

0.081

1.21 [0.98–1.49]

0.109

0.87 [0.74–1.03]

0.003

0.72 [0.58–0.90]

G

378 (18.9)

141 (16.2)

314 (21.1)

      

C/C

659 (66.0)

302 (69.4)

459 (61.8)

0.098

 

0.174

 

0.010

 

C/G

300 (30.1)

125 (28.7)

254 (34.2)

      

G/G

39 (3.9)

8 (1.8)

30 (4.0)

      

rs2297538

G

1705 (85.4)

723 (83.1)

1261 (84.9)

0.113

1.19 [0.96–1.48]

0.644

1.05 [0.87–1.26]

0.259

0.88 [0.70–1.10]

A

291 (14.6)

147 (16.9)

225 (15.1)

      

G/G

737 (73.8)

315 (72.4)

535 (72.0)

0.016

 

0.339

 

0.001

 

G/A

231 (23.1)

93 (21.4)

191 (25.7)

      

A/A

30 (3.0)

27 (6.2)

17 (2.3)

      

rs2227255

T

1376 (68.9)

600 (69.0)

1005 (67.6)

0.988

1.00 [0.84–1.19]

0.412

1.06 [0.92–1.23]

0.502

1.06 [0.89–1.28]

C

620 (31.1)

270 (31.0)

481 (32.4)

      

T/T

474 (47.5)

205 (47.1)

350 (47.1)

0.946

 

0.309

 

0.329

 

T/C

428 (42.9)

190 (43.7)

305 (41.0)

      

C/C

96 (9.6)

40 (9.2)

88 (11.8)

      

rs2227258

G

1387 (69.5)

604 (69.4)

1002 (67.4)

0.973

1.00 [0.84–1.19]

0.195

1.10 [0.95–1.27]

0.316

1.10 [0.92–1.31]

A

609 (30.5)

266 (30.6)

484 (32.6)

      

G/G

481 (48.2)

207 (47.6)

349 (47.0)

0.911

 

0.147

 

0.183

 

G/A

425 (42.6)

190 (43.7)

304 (40.9)

      

A/A

92 (9.2)

38 (8.7)

90 (12.1)

      
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