Fig. 4
From: CML derived exosomes promote tumor favorable functional performance in T cells
The effects of K562 derived exosomes on morphology, gene expression profile, and cytokine secretion of cord blood T cells, a Shows untreated control, b Shows the aggregation of cord blood T cells after treatment with 100 μg/ml concentration of K562 derived exosomes, c the effects of K562 derived exosomes on c-myc, NQO1, PI3K, PD1, CD3d, ITK, NFATc3, NFARc4, and FOXP3 expression, d The effects of K562 derived exosomes on the expression of TGF-β, TNF-α, IL-10, IL-6 and IL-17 in cord blood T cells, e The effects of K562 derived exosomes on TNF-α, IL-1β, IL-8, IL-6, IL-10 and IL-17 secretion from cord blood T cells. Data represented as mean ± SD (error bars) of three independent experiments in triplicate assays (***; P-value < 0.001, **; P-value < 0.01 and *; P-value < 0.05)