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Table 3 Review of the literature about RAS-mutant gliomas

From: Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

Author (publish year) Target of the study Age Sex Histology RAS mutation Other mutations
Maltzman (1997) [38] 46 brain tumors 5 F fibrillary astrocytoma NRAS Q61E  
  12 F fibrillary astrocytoma NRAS Q61E  
  4 F pilocytic astrocytoma NRAS Q61E  
Knobbe (2004) [39] 94 glioblastomas NA NA glioblastoma NRAS G12D  
  NA NA gliosarcoma NRAS G12D  
Janzarik (2007) [40] 25 astrocytoma NA NA pilocytic astrocytoma KRAS G12A  
Jeuken (2007) [41] 93 gliomas NA NA anaplastic oligodendroglioma NRAS G10E  
Schiffman(2010) [42] 41 astrocytomas 14 NA glioblastoma KRAS G12V  
Cin(2011) [43] 125 pilocytic astrocytomas 11 NA Pilocytic astrocytoma KRAS E63K  
  1 NA Pilocytic astrocytoma KRAS G12A  
Chi (2012) [24] 218 gliomas NA NA glioblastoma KRAS G61R  
  NA NA glioblastoma with oligodendroglioma component KRAS G12A IDH1 R132H
  NA NA glioblastoma KRAS G12C  
Theeler (2014 [44]) 40 pilocytic astrocytoma 18 M pilocytic astrocytoma NRAS G12D  
  25 M pilocytic astrocytoma NRAS G12D  
  34 M pilocytic astrocytoma NRAS G12D  
  46 M pilocytic astrocytoma KRAS G12S BRAF-KIAA 1549 fusion
Milinkovic (2014 [45]) 5 cerebellar glioblastomas 42 M glioblastoma KRAS c.7_8insT, HRAS T4H TP53 R273P
  41 M glioblastoma KRAS c.7_8insT, HRAS T4H TP53 exon9 deletion, G298D(second surgery)
  64 M glioblastoma HRAS T4H  
  36 M glioblastoma KRAS c.177_178insA, HRAS T4H TP53 C176R
  49 M glioblastoma HRAS exon2 insertion  
Wakimoto (2014) [26] 20 gliomas. IDH-mutant 60 M oligoastrocytoma KRAS G12R IDH1 R132H, AKT1 E17K, PIK3CA H1047L, 1p/19q codeletion
  41 F astrocytoma KRAS G13D IDH1 R132H, 1p/19q codeletion
  33 F oligodendroglioma KRAS G13R IDH1 R132H, 1p/19q codeletion
  54 M glioblastoma with oligodendroglioma component KRAS G12A IDH1 R132H, 1p/19q codeletion
Samel (2016) [46] case report 44 F glioblastoma (high grade area) KRAS exon2 EGFR exon18, BRAF exon15, TP53(IHC expression)
Ballester (2017) [47] 381 diffuse gliomas NA NA anaplastic oligodendroglioma KRAS G60S IDH1R132H, CDKN2A P75L, JAK3 G712D, MPL A519T
  NA NA anaplastic oligodendroglioma KRAS G12D  
  NA NA glioblastoma KRAS G12A IDH1 R132H, TP53 Q104*
  NA NA glioblastoma KRAS A146T IDH1 R132H, CDKN2A R58, KIT A814V, PIK3CA E545K, TP53 G245S
  NA NA glioblastoma NRAS Q61K TP53 E180K
  NA NA glioblastoma NRAS Q61K  
  NA NA oligodendroglioma NRAS G12C IDH1 R132H
Pekmezci (2018) [25] 40 gangliogliomas 32 F ganglioglioma KRAS Q61K  
  24 M ganglioglioma KRAS Q61K  
Reinhardt (2018 [48]) 64 anaplastic pilocytic astrocytomas NA F anaplastic pilocytic astrocytoma KRAS Q61H MAPK alteration, CDKN2A/B deletion/mutation, ATRX loss/mutation, MGMTp methylation
  NA F anaplastic pilocytic astrocytoma KRAS V14A MAPK alteration, CDKN2A/B deletion/mutation, ATRX loss/mutation, MGMTp methylation
Chau (2019) [49] case report 24 F pilocytic astrocytoma KRAS E63K RAD1 F475L, NOTCH3 S502F, JAK1 c.6 + 1G > T
Shittenhelm (2019) [50] 186 gliomas 51 M oligodendroglioma KRAS G12R IDH1 mutant, 1p/19q codeletion, TERTp
  48 F oligodendroglioma KRAS G12C IDH1 mutant, 1p/19q codeletion, TERTp
  39 F glioblastoma KRAS Q61L TERTp mutation
Zou (2019) [51] 13 pleomorphic xanthoastrocytomas 50 M pleomorphic xanthoastrocytoma KRAS Q61H NOTCH2 R2298W, MEN1 G219, CHEK1 P318A, PARP4 L482F, FANC1 L1253V, FANCA Q1437K, TP53 R248Q, NOTCH3 R1666W, CCNE1 I298, NOTCH1 N454
  29 F pleomorphic xanthoastrocytoma KRAS Q61K  
  1. NA Not available