Table 3 Review of the literature about RAS-mutant gliomas
From: Infrequent RAS mutation is not associated with specific histological phenotype in gliomas
| Author (publish year) | Target of the study | Age | Sex | Histology | RAS mutation | Other mutations |
|---|---|---|---|---|---|---|
| Maltzman (1997) [38] | 46 brain tumors | 5 | F | fibrillary astrocytoma | NRAS Q61E | |
| 12 | F | fibrillary astrocytoma | NRAS Q61E | |||
| 4 | F | pilocytic astrocytoma | NRAS Q61E | |||
| Knobbe (2004) [39] | 94 glioblastomas | NA | NA | glioblastoma | NRAS G12D | |
| NA | NA | gliosarcoma | NRAS G12D | |||
| Janzarik (2007) [40] | 25 astrocytoma | NA | NA | pilocytic astrocytoma | KRAS G12A | |
| Jeuken (2007) [41] | 93 gliomas | NA | NA | anaplastic oligodendroglioma | NRAS G10E | |
| Schiffman(2010) [42] | 41 astrocytomas | 14 | NA | glioblastoma | KRAS G12V | |
| Cin(2011) [43] | 125 pilocytic astrocytomas | 11 | NA | Pilocytic astrocytoma | KRAS E63K | |
| 1 | NA | Pilocytic astrocytoma | KRAS G12A | |||
| Chi (2012) [24] | 218 gliomas | NA | NA | glioblastoma | KRAS G61R | |
| NA | NA | glioblastoma with oligodendroglioma component | KRAS G12A | IDH1 R132H | ||
| NA | NA | glioblastoma | KRAS G12C | |||
| Theeler (2014 [44]) | 40 pilocytic astrocytoma | 18 | M | pilocytic astrocytoma | NRAS G12D | |
| 25 | M | pilocytic astrocytoma | NRAS G12D | |||
| 34 | M | pilocytic astrocytoma | NRAS G12D | |||
| 46 | M | pilocytic astrocytoma | KRAS G12S | BRAF-KIAA 1549 fusion | ||
| Milinkovic (2014 [45]) | 5 cerebellar glioblastomas | 42 | M | glioblastoma | KRAS c.7_8insT, HRAS T4H | TP53 R273P |
| 41 | M | glioblastoma | KRAS c.7_8insT, HRAS T4H | TP53 exon9 deletion, G298D(second surgery) | ||
| 64 | M | glioblastoma | HRAS T4H | |||
| 36 | M | glioblastoma | KRAS c.177_178insA, HRAS T4H | TP53 C176R | ||
| 49 | M | glioblastoma | HRAS exon2 insertion | |||
| Wakimoto (2014) [26] | 20 gliomas. IDH-mutant | 60 | M | oligoastrocytoma | KRAS G12R | IDH1 R132H, AKT1 E17K, PIK3CA H1047L, 1p/19q codeletion |
| 41 | F | astrocytoma | KRAS G13D | IDH1 R132H, 1p/19q codeletion | ||
| 33 | F | oligodendroglioma | KRAS G13R | IDH1 R132H, 1p/19q codeletion | ||
| 54 | M | glioblastoma with oligodendroglioma component | KRAS G12A | IDH1 R132H, 1p/19q codeletion | ||
| Samel (2016) [46] | case report | 44 | F | glioblastoma (high grade area) | KRAS exon2 | EGFR exon18, BRAF exon15, TP53(IHC expression) |
| Ballester (2017) [47] | 381 diffuse gliomas | NA | NA | anaplastic oligodendroglioma | KRAS G60S | IDH1R132H, CDKN2A P75L, JAK3 G712D, MPL A519T |
| NA | NA | anaplastic oligodendroglioma | KRAS G12D | |||
| NA | NA | glioblastoma | KRAS G12A | IDH1 R132H, TP53 Q104* | ||
| NA | NA | glioblastoma | KRAS A146T | IDH1 R132H, CDKN2A R58, KIT A814V, PIK3CA E545K, TP53 G245S | ||
| NA | NA | glioblastoma | NRAS Q61K | TP53 E180K | ||
| NA | NA | glioblastoma | NRAS Q61K | |||
| NA | NA | oligodendroglioma | NRAS G12C | IDH1 R132H | ||
| Pekmezci (2018) [25] | 40 gangliogliomas | 32 | F | ganglioglioma | KRAS Q61K | |
| 24 | M | ganglioglioma | KRAS Q61K | |||
| Reinhardt (2018 [48]) | 64 anaplastic pilocytic astrocytomas | NA | F | anaplastic pilocytic astrocytoma | KRAS Q61H | MAPK alteration, CDKN2A/B deletion/mutation, ATRX loss/mutation, MGMTp methylation |
| NA | F | anaplastic pilocytic astrocytoma | KRAS V14A | MAPK alteration, CDKN2A/B deletion/mutation, ATRX loss/mutation, MGMTp methylation | ||
| Chau (2019) [49] | case report | 24 | F | pilocytic astrocytoma | KRAS E63K | RAD1 F475L, NOTCH3 S502F, JAK1 c.6 + 1G > T |
| Shittenhelm (2019) [50] | 186 gliomas | 51 | M | oligodendroglioma | KRAS G12R | IDH1 mutant, 1p/19q codeletion, TERTp |
| 48 | F | oligodendroglioma | KRAS G12C | IDH1 mutant, 1p/19q codeletion, TERTp | ||
| 39 | F | glioblastoma | KRAS Q61L | TERTp mutation | ||
| Zou (2019) [51] | 13 pleomorphic xanthoastrocytomas | 50 | M | pleomorphic xanthoastrocytoma | KRAS Q61H | NOTCH2 R2298W, MEN1 G219, CHEK1 P318A, PARP4 L482F, FANC1 L1253V, FANCA Q1437K, TP53 R248Q, NOTCH3 R1666W, CCNE1 I298, NOTCH1 N454 |
| 29 | F | pleomorphic xanthoastrocytoma | KRAS Q61K |