Infrequent RAS mutation is not associated with specific histological phenotype in gliomas

BMC Cancer

Table 1 Number of mutations in each type of glioma

	Number of cases	Driver gene mutations					1p/19q codeleted	*MGMT*p hypermethyl	*RAS* mutations
	Number of cases	*IDH1*	*IDH2*	*H3F3A*	*HIST1H3B*	*TERT*p	1p/19q codeleted	*MGMT*p hypermethyl	*KRAS*	*HRAS*	*NRAS*
DA, **IDH-mutant**	20	20	0	0	0	1	0	13	0	0	0
DA, **IDH-wild type**	18	0	0	0	0	8	0	7	0	0	0
AA, **IDH-mutant**	11	10	1	0	0	0	0	5	0	0	0
AA, **IDH-wild type**	32	0	0	0	0	15	0	10	1	0	1
GBM, **IDH-mutant**	4	4	0	0	0	0	0	2	0	0	0
GBM, **IDH-wildtype**	94	0	0	0	0	39	0	31	0	0	0
gliosarcoma	1	0	0	0	0	0	0	0	0	0	0
OD, **IDH-mutant and 1p/19q codeleted**	22	18	4	0	0	20	22	20	0	0	0
OD, NOS	4	2	1	0	0	3	0	2	0	0	0
AO, *IDH* mutant and 1p/19q codeleted	15	12	3	0	0	15	15	12	1	0	0
diffuse midline glioma, *H3K27M* mutant	9	0	0	8	1	1	0	1	0	0	0
ganglioglioma	1	0	0	0	0	0	0	0	1	0	0
PA	7	0	0	0	0	0	0	1	0	0	0
PMA	1	0	0	0	0	0	0	0	0	0	0
PXA	2	0	0	0	0	0	0	0	0	0	0
APXA	1	0	0	0	0	0	0	0	0	0	0
Total	242	66	9	8	1	102	37	104	3	0	1

DA Diffuse astrocytoma, AA Anaplastic astrocytoma, GBM Glioblastoma, OD Oligodendroglioma, AO Anaplastic oligodendroglioma, PA Pilocytic astrocytoma, PMA Pilomyxoid astrocytoma, PXA Pleomorphic xanthoastrocytoma, APXA Anaplastic pleomorphic xanthoastrocytoma, TERTp TERT promoter, MGMTp MGMT promoter

ISSN: 1471-2407