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Fig. 6 | BMC Cancer

Fig. 6

From: LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression

Fig. 6

LINC00852 knockdown inhibits ovarian cancer and AGTR1/MEK/ERK/STAT3 pathway in vivo. SKOV-3 cells transfected with sh-LINC00852-1 or sh-NC were subcutaneously injected into nude mice. Tumor tissues were collected at day 42. a-b Tumor volume was suppressed in sh-LINC00852-1 group than sh-NC group, whereas there was no significant differences between control and sh-NC groups. c Tumor weight was inhibited in sh-LINC00852-1 group than sh-NC group. d Body weight of mice in control, sh-NC, sh-LINC00852-1 groups at 1, 2, 3, 4, 5 and 6 weeks. e LINC00852 and miR-140-3p expression in tumor tissues of sh-LINC00852-1 group, control and sh-NC group were detected by qRT-PCR. f Protein levels of AGTR1, MEK, p-MEK, ERK1/2, p-ERK1/2, STAT3 and p-STAT3 in tumor tissues of sh-LINC00852-1 group and sh-NC group were detected by Western blotting. g The expressions of invasion marker MMP-2, MMP-9, Ki67 and PCNA were detected by IHC staining. h-i The average number of lung metastasis tumors per mouse in control, sh-NC and sh-LINC00852 groups . *p < 0.05, compared with control group

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