Fig. 4

miR-140-3p overexpression reverses the promotion effect of LINC00852 on the proliferation and invasion of ovarian cancer cells. a miR-140-3p expression in ovarian cancer tissues and adjacent normal tissues was detected by qRT-PCR. N = 85. SKOV-3 cells were transfected with oe-NC + mimic NC, oe-NC + miR-140-3p mimic, and oe-LINC00852 + miR-140-3p mimic. b miR-140-3p expression in SKOV-3 cells was detected by qRT-PCR. c The viability of SKOV-3 cells was detected by CCK-8 assay. d The colony formation ability of SKOV-3 cells was detected by colony formation assay. e The apoptosis rate of SKOV-3 cells was observed by Hoechst 33342 staining. f The invasion rate of SKOV-3 cells was detected by Transwell assay. g-h Protein levels of MMP-2, MMP-9, Ki67, PCNA, cleaved caspase-3 and cleaved PARP in SKOV-3 cells were detected by Western blotting. I. Gelatine zymography analyses showed enzymatic forms of MMP-2 and MMP-9. *p < 0.05, oe-NC + mimic NC compared with oe-NC + miR-140-3p mimic, #p < 0.05, oe-NC + miR-140-3p mimic compared with oe-LINC00852 + miR-140-3p mimic