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Fig. 2 | BMC Cancer

Fig. 2

From: LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression

Fig. 2

LINC00852 knockdown inhibits the proliferation and invasion of ovarian cancer cells. a SKOV-3 and OV-90 cells were transfected with sh-LINC00852-1, sh-LINC00852-2, and sh-LINC00852-3, then LINC00852 expression was detected in SKOV-3 and OV-90 cells with different transfections. b The viability of SKOV-3 and OV-90 cells at different groups was detected by CCK-8 assay. c The colony formation ability of SKOV-3 and OV-90 cells at different groups was detected by colony formation assay. d The apoptosis rate of SKOV-3 and OV-90 cells at different groups was observed by Hoechst 33342 staining. e The invasion rate of SKOV-3 and OV-90 cells at different groups was detected by Transwell assay. f-g Protein levels of MMP-2, MMP-9, Ki67, PCNA, apoptosis markers cleaved caspase-3 and cleaved PARP in SKOV-3 and OV-90 cells at different groups were measured by Western blotting. H. Gelatine zymography analyses showed enzymatic forms of MMP-2 and MMP-9. *p < 0.05, compared with control

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