Fig. 4
From: Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans
miR-182 targets PDCD4 and contributes to aggressiveness in AA prostate cancer patients. A PDCD4 expression levels in prostate cell lines DU-145, LNCaP, and MDA-PCa-2b transfected with miR-182 inhibitor assessed by Western blot. B PDCD4-binding site for miR-182. C Luciferase reporter assay using vectors containing PDCD4-binding site. D PDCD4 staining by IHC in EA and AA patients. E and F PDCD4 expression in SFVAMC (E) or TCGA (F) patients with high and low Gleason grade. Grade 1: Gleason score 6 or less; Grade 2: Gleason score 3 + 4; Grade 3: Gleason score 4 + 3; Grade 4: Gleason score 8; Grade 5: Gleason scores 9–10 [29]. *, P < 0.05. Data are presented mean ± SD in C