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Fig. 5 | BMC Cancer

Fig. 5

From: Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells

Fig. 5

Impacts of paclitaxel and ultrasound on microtubule filaments. A Breast and ovarian cancer cells (MCF-7, OVCAR3,OVCAR5, OVCAR4, OVCAR8, OVCAR10, and A2780) were treated with paclitaxel (1 nM, Taxol), and in 8 h, the cells on tissue culture dish were exposed to ultrasound (+ US, 40 KHz, 1 W/cm2) for 5 min. Following ultrasound treatment, at 0.2, and 24 h, the cells were fixed and processed for immunostaining for alpha-tubulin. An example of OVCAR5 cells is shown. B Cells were treated with paclitaxel (1 nM, Taxol), and in 8 h, the cells on tissue culture dish were exposed to ultrasound (+ US, 40 KHz, 1 W/cm2) for 5 min. Following ultrasound treatment, at 0, 5, 15, 30 and 60 min, the cells were fixed and processed for analyses by immunofluorescence microscopy for alpha tubulins. A representative example of A2780 cells is shown

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