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Table 2 Hazard ratios (95% confident intervals) of esophageal cancer according to quintiles of energy-adjusted dietary intakes of vitamin B12, vitamin B6, folate, and methionine

From: Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study

 

Q1

Q2

Q3

Q4

Q5

p-trenda

Vitamin B12

 Person-years

296,280

292,419

290,662

289,062

288,256

 

 Cases, n

80

72

82

87

106

 

 Model 1b

1.00 (reference)

0.93 (0.68–1.28)

1.00 (0.73–1.37)

1.00 (0.73–1.37)

1.13 (0.83–1.52)

0.31

 Model 2c

1.00 (reference)

1.09 (0.79–1.51)

1.25 (0.91–1.72)

1.28 (0.93–1.76)

1.37 (1.00–1.86)

0.04

 Model 3d

1.00 (reference)

1.13 (0.80–1.59)

1.43 (0.99–2.06)

1.58 (1.07–2.34)

1.75 (1.13–2.71)

0.01

3-year exclusion analysis

 Cases, n

71

64

71

79

91

 

 Model 3d

1.00 (reference)

1.13 (0.79–1.63)

1.40 (0.95–2.06)

1.64 (1.08–2.48)

1.74 (1.09–2.78)

0.02

Vitamin B6

 Person-years

296,267

294,533

291,293

288,886

285,698

 

 Cases, n

75

78

82

86

106

 

 Model 1b

1.00 (reference)

1.01 (0.73–1.39)

0.87 (0.63–1.19)

0.78 (0.57–1.07)

0.81 (0.60–1.09)

0.08

 Model 2c

1.00 (reference)

1.24 (0.90–1.71)

1.16 (0.84–1.60)

1.08 (0.78–1.49)

1.08 (0.79–1.48)

0.98

 Model 3d

1.00 (reference)

1.17 (0.83–1.64)

1.04 (0.72–1.48)

0.89 (0.61–1.30)

0.81 (0.53–1.24)

0.16

3-year exclusion analysis

 Cases, n

65

70

73

75

93

 

 Model 3d

1.00 (reference)

1.22 (0.85–1.76)

1.09 (0.74–1.60)

0.94 (0.63–1.42)

0.89 (0.57–1.40)

0.36

Folate

 Person-years

292,275

290,461

290,196

292,381

291,364

 

 Cases, n

107

83

79

89

69

 

 Model 1b

1.00 (reference)

0.80 (0.60–1.07)

0.81 (0.60–1.08)

0.88 (0.66–1.17)

0.67 (0.49–0.92)

0.03

 Model 2c

1.00 (reference)

1.02 (0.76–1.37)

1.10 (0.82–1.49)

1.24 (0.93–1.67)

1.00 (0.72–1.37)

0.71

 Model 3d

1.00 (reference)

1.01 (0.74–1.36)

1.10 (0.80–1.51)

1.27 (0.92–1.75)

1.07 (0.74–1.55)

0.50

3-year exclusion analysis

 Cases, n

95

71

76

74

60

 

 Model 3d

1.00 (reference)

0.97 (0.70–1.34)

1.19 (0.85–1.65)

1.18 (0.84–1.68)

1.04 (0.70–1.54)

0.65

Methionine

 Person-years

293,843

294,206

291,479

289,686

287,464

 

 Cases, n

107

92

53

74

101

 

 Model 1b

1.00 (reference)

0.98 (0.74–1.29)

0.51 (0.37–0.71)

0.60 (0.45–0.81)

0.69 (0.53–0.91)

0.001

 Model 2c

1.00 (reference)

1.29 (0.97–1.72)

0.77 (0.55–1.09)

1.02 (0.74–1.40)

1.19 (0.88–1.60)

0.46

 Model 3d

1.00 (reference)

1.10 (0.80–1.50)

0.61 (0.41–0.90)

0.77 (0.52–1.15)

0.91 (0.59–1.40)

0.53

3-year exclusion analysis

 Cases, n

96

81

48

66

85

 

 Model 3d

1.00 (reference)

1.08 (0.77–1.51)

0.62 (0.41–0.93)

0.76 (0.50–1.15)

0.83 (0.53–1.31)

0.34

  1. a Median values of vitamin B12, vitamin B6, folate, and methionine intakes in each quintile were used to test for a linear trend across .
  2. b Model 1 was adjusted for age, sex, and public health center area.
  3. c Model 2 was adjusted for age, sex, public health center area, body mass index (quintiles), smoking (never, past, current; ≤19 cigarettes/day, 20–29 cigarettes/day, or ≥30 cigarettes/day), alcohol consumption (non-drinkers, ≤150 g/week, 150<alcohol≤300 g/week, 300<alcohol<450 g/week, or ≤450 g/week), family history of cancer, and physical activity in METs (quintiles).
  4. d Model 3 was model 2 that was mutually adjusted further for vitamin B12, vitamin B6, folate, and methionine
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BMC Cancer

ISSN: 1471-2407

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