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Table 1 Clinical characteristics of breast cancers in mutation carriers and non-carriers

From: Genetic predisposition to male breast cancer in Poland

Mutation BRCA1 BRCA2 PALB2 CHEK2 truncating CHEK2 c.470C > T NBN Non-carriers
N Tot % N Tot % N Tot % N Tot % N Tot % N Tot % N Tot %
Histology
 Ductal 1 1 100.0 2 2 100.0 3 3 100.0 4 4 100.0 7 8 87.5 1 1 100.0 111 125 88.8
 Lobular 0 1 0.0 0 2 0.0 0 3 0.0 0 4 0.0 0 8 0.0 0 1 0.0 6 125 4.8
 Other 0 1 0.0 0 2 0.0 0 3 0.0 0 4 0.0 1 8 12.5 0 1 0.0 8 125 6.4
Tumour size
 T1/T2 0 1 0.0 2 2 100.0 2 3 66.7 3 3 100.0 7 7 100.0 1 1 100.0 83 110 75.5
 T3/T4 1 1 100.0 0 2 0.0 1 3 33.3 0 3 0.0 0 7 0.0 0 1 0.0 27 110 24.5
ER positive 1 1 100.0 1 1 100.0 3 3 100.0 4 4 100.0 7 7 100.0 1 1 100.0 100 111 90.0
PR positive 1 1 100.0 1 1 100.0 3 3 100.0 4 4 100.0 7 7 100.0 1 1 100.0 88 110 80.0
HER2 positive 0 1 0.0 0 1 0.0 0 3 0.0 0 4 0.0 1 7 14.3 1 1 100.0 11 108 10.2
Triple negative 0 1 0.0 0 1 0.0 0 3 0.0 0 4 0.0 0 7 0.0 0 1 0.0 11 107 10.3
Lymph nodes positive 0 1 0.0 2 2 100.0 1 3 33.3 1 3 33.3 1 7 14.3 0 1 0.0 53 104 51.0
Bilateral 0 1 0.0 0 2 0.0 2 4 50.0 0 5 0.0 0 9 0.0 0 1 0.0 0 143 0.0
Multiple primary cancers 0 1 0.0 2 2 100.0 2 4 50.0 1 5 20.0 3 9 33.3 0 1 0.0 12 143 8.4
Family history positive
 Breast 1 1 100.0 1 2 50.0 3 4 75.0 2 5 40..0 2 9 22.2 0 1 0.0 38 143 26.6
 Ovarian 0 1 0.0 0 2 0.0 1 4 25.0 0 5 0.0 0 9 0.0 0 1 0.0 6 143 4.2
 Other 0 1 0.0 1 2 50.0 0 4 0.0 3 5 60.0 5 9 55.6 0 1 0.0 51 143 35.7
Age of diagnosis
  < 50 0 1 0.0 0 2 0.0 2 4 50.0 1 5 20.0 2 9 22.2 0 1 0.0 20 143 14.0
  ≥ 50 1 1 100.0 2 2 100.0 2 4 50.0 4 5 80.0 7 9 77.8 1 1 100.0 123 143 86.0
Median age of diagnosis (range) 74 69 (62–76) 57 (42–77) 62 (33–70) 64 (34–72) 62 63 (26–89)