Adjuvant chemotherapy is an additional option for locally advanced gastric cancer after radical gastrectomy with D2 lymphadenectomy: a retrospective control study

Table 5 Univariate and multivariate analysis of clinicopathologic factors for OS

Variables	Univariate			Multivariate
Variables	HR	95% CI	P	HR	95% CI	P
Age (years)
< 60 yr	1.000			1.000
≥ 60 yr	1.540	1.107–2.141	0.010	1.418	1.000–2.011	0.050
Sex
Male	1.000
Female	1.105	0.777–1.571	0.577
BMI
< 23	1.000
≥ 23	1.020	0.735–1.417	0.905
Surgical approach
Traditional open	1.000
Laparoscopic-assisted	0.918	0.640–1.318	0.644			0.769
Intraoperative blood loss
≤ 100 ml	1.000			1.000
>100 ml	1.740	1.191–2.527	0.004	1.780	1.211–2.617	0.003
Postoperative complications
Negative	1.000
Positive	1.551	1.001–2.404	0.050			0.729
Tumor length/diameter
< 5 cm	1.000
≥ 5 cm	1.738	1.254–2.408	0.001			0.288
Histological type
HD/MD/M-LD	1.000
LD/MA/SRC	1.489	1.072–2.068	0.018			0.094
Vascular tumor embolus
Negative	1.000
Positive	1.956	1.372–2.789	< 0.001			0.626
Depth of Invasion (T)
T1/T2/T3	1.000
T4a/T4b	2.133	1.525–2.983	< 0.001			0.526
Lymph node metastasis (N)
N0/N1	1.000
N2/N3	3.247	2.227–4.736	< 0.001			0.336
TNM			< 0.001			< 0.001
IIA	1.000
IIB	2.905	1.263–6.680	0.012	2.667	1.158–6.142	0.021
IIIA	4.375	2.067–9.259	< 0.001	4.579	2.162–9.697	< 0.001
IIIB	8.092	3.817–17.156	< 0.001	9.092	4.277–19.327	< 0.001
IIIC	14.987	6.776–33.145	< 0.001	16.948	7.627–37.662	< 0.001
Serum CEA level
≤ 5 ng/ml	1.000
>5 ng/ml	1.183	0.802–1.744	0.396
Serum CA199 level
≤ 37 U/ml	1.000
>37 U/ml	1.333	1.082–1.644	0.007			0.981
Adjuvant chemotherapy cycles			< 0.001			< 0.001
Not received (A)	1.000			1.000
7–8 or 10–12 cycles (B)	0.459	0.301–0.699	< 0.001	0.386	0.247–0.604	< 0.001
4–6 or 6–9 cycles (C)	0.504	0.314–0.807	0.004	0.493	0.304–0.800	0.004
≤ 3 or 5 cycles (D)	1.032	0.638–1.670	0.897	0.870	0.530–1.427	0.580

Note: HD/MD/M-LD High/Median/Median-Low differentiation adenocarcinoma, LD/MA/SRC Low differentiation adenocarcinoma/Mucinous adeno-carcinoma/ Signet-ring cell carcinoma, HR Hazard ratio, CI Confidence interval. P < 0.05, statistically significant

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