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Fig. 7 | BMC Cancer

Fig. 7

From: Long non-coding RNAs HERH-1 and HERH-4 facilitate cyclin A2 expression and accelerate cell cycle progression in advanced hepatocellular carcinoma

Fig. 7

Schematic summary of lncRNAs HERH-1/4 mediated cell cycle acceleration in the advanced HCC cells. HERH-1 bound with the transcription factor CREB1 and facilitated its promotion on CCNA2 transcription. HERH-4 acted as a ceRNA to absorb miR-29b/c and shield CCNA2 mRNA from degradation. These two lncRNAs enhanced CCNA2 expression and accelerated HCC cell cycle progression. These pathways may be part of the mechanism of HCC progression

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BMC Cancer

ISSN: 1471-2407

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