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Fig. 5 | BMC Cancer

Fig. 5

From: Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma

Fig. 5

ERp44 was enriched in ERS-exosomes and could strengthen chemoresistance in NPC. A: Western blot was used to detect ERp44 expression in exosomes from NPC patients and normal volunteers. The histogram showed ERp44 expression relative to Flotillion-1. B: Western blot showed the expression of GRP78 with the treatment of different concentrations of tunicamycin (TM) for 24 h. C: Western blot showed the expression of GRP78 with the treatment of 1.5 μM TM for different time points (0 h,3 h,6 h,12 h,24 h,48 h). D: Western blot showed ERp44 expression level in exosomes with the treatment of TM (1.5 μM) for 24 h. E: Western blot showed the expression of GRP78 and ERp44 after the treatment of TM-exosomes, F: Western blot showed the expression of ERp44 in exosomes when ERp44 was knocked down. G: CCK8 assay showed that cell viability was decreased after the treatment of shERp44-exosomes. H: CCK8 assay showed chemosensitivity of CNE2 was increased with the treatment of shERp44-exosomes. * P < 0.05

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