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Table 2 Risk of non-cancer deaths for the 25 major types of non-cancer causes within the first year after diagnosis among cancer patients

From: Immediate risk of non-cancer deaths after a cancer diagnosis

Cause

No. of observed deaths

Mortality rate

No. of expected deaths

SMR (95% CI)

Cardiovascular diseases

105,518 (21.8%)

1875.9

52,130.6

2.02 (2.01–2.04)

 Diseases of heart

82,346 (17.0%)

1464.0

39,992.2

2.06 (2.05–2.07)

 Cerebrovascular diseases

15,959 (3.3%)

283.7

8718.0

1.83 (1.80–1.86)

 Hypertension without heart disease

3039 (0.6%)

54.0

1303.7

2.33 (2.25–2.42)

 Aortic aneurysm and dissection

1522 (0.3%)

27.1

865.2

1.76 (1.67–1.85)

 Atherosclerosis

1468 (0.3%)

26.1

675.5

2.17 (2.06–2.29)

 Other diseases of arteries, arterioles, capillaries

1184 (0.2%)

21.0

573.9

2.06 (1.95–2.18)

Infectious diseases

34,997 (7.2%)

622.2

6889.5

5.08 (5.03–5.13)

 Pneumonia and influenza

9799 (2.0%)

174.2

3849.7

2.55 (2.50–2.60)

 Syphilis

3 (0.001%)

0.1

1.1

2.65 (0.85–8.21)

 Tuberculosis

157 (0.03%)

2.8

48.9

3.21 (2.75–3.75)

 Septicemia

7185 (1.5%)

127.7

1870.2

3.84 (3.75–3.93)

 Other infectious and parasitic diseases including HIV

17,853 (3.7%)

317.4

856.8

20.84 (20.53–21.14)

Respiratory diseases

21,229 (4.4%)

377.4

8188.6

2.59 (2.56–2.63)

 Chronic obstructive pulmonary disease and allied cond

21,229 (4.4%)

377.4

8188.6

2.59 (2.56–2.63)

Gastrointestinal and liver diseases

7338 (1.5%)

130.5

1588.8

4.62 (4.51–4.73)

 Stomach and duodenal ulcers

990 (0.2%)

17.6

238.2

4.16 (3.91–4.42)

 Chronic liver disease and cirrhosis

6348 (1.3%)

112.9

1349.8

4.70 (4.59–4.82)

Renal diseases

5678 (1.2%)

100.9

2481.6

2.29 (2.23–2.35)

 Nephritis, nephrotic syndrome and nephrosis

5678 (1.2%)

100.9

2481.6

2.29 (2.23–2.35)

External injuries

8875 (1.8%)

157.8

4755.9

1.87 (1.83–1.91)

 Accidents and adverse effects

6009 (1.2%)

106.8

3614.9

1.66 (1.62–1.70)

 Suicide and self-inflicted injury

2653 (0.5%)

47.2

931.6

2.85 (2.74–2.96)

 Homicide and legal intervention

213 (0.04%)

3.8

208.1

1.02 (0.90–1.17)

Other non-cancer causes of death

57,940 (12.0%)

1030.1

27,070.3

2.14 (2.12–2.16)

 Alzheimers

3146 (0.7%)

55.9

3728.7

0.84 (0.81–0.87)

 Diabetes mellitus

7263 (1.5%)

129.1

4093.4

1.77 (1.73–1.82)

 Congenital anomalies

446 (0.1%)

7.9

144.8

3.08 (2.81–3.38)

 Certain conditions originating in perinatal period

50 (0.01%)

0.9

15.5

3.22 (2.44–4.25)

 Complications of pregnancy, childbirth, puerperiuma

173 (0.04%)

3.1

4.7

36.62 (31.55–42.50)

 Symptoms, signs and ill-defined conditions

3921 (0.8%)

69.7

1390.4

2.82 (2.73–2.91)

 Other cause of death

42,941 (8.9%)

763.4

17,689.8

2.43 (2.40–2.45)

  1. Abbreviations: SMR, standardized mortality ratio; CI, confidence interval; HIV, human immunodeficiency virus
  2. a For the deaths from complications of pregnancy, childbirth, puerperium, which occurred only in female patients, the SMR reference population was the female general population in the United States from 1990 through 2015. For the other causes, the SMR reference population was the entire US population from 1990 through 2015