Skip to main content

Table 1 Risk of non-cancer deaths among patients with cancer by demographic and tumor characteristics for the non-cancer deaths occurred within the first year or after a year following diagnosis

From: Immediate risk of non-cancer deaths after a cancer diagnosis

Characteristics

Within 1 years since diagnosis

More than 1 year since diagnosis

No. of patients with cancer

Person-years of follow up

No. of observed deaths

No. of expected deaths

SMRa (95% CI)

No. of patients with cancer

Person-years of follow up

No. of observed deaths

No. of expected deaths

SMRa (95% CI)

All

7,366,229 (100%)

5,624,828

241,575 (100.0%)

103,105.6

2.34 (2.33–2.35)

5,425,172 (100%)

36,196,870

864,975 (100.0%)

478,513.4

1.81 (1.80–1.81)

Age, y

 0–19

92,844 (1.3%)

78,747

583 (0.2%)

54.7

10.66 (9.83–11.57)

79,811 (1.5%)

669,075

1080 (0.1%)

502.5

2.15 (2.03–2.28)

 20–39

442,398 (6.0%)

372,394

7364 (3.0%)

370.4

19.88 (19.43–20.34)

377,627 (7.0%)

3,211,248

11,940 (1.4%)

3160.8

3.78 (3.71–3.85)

 40–59

2,234,414 (30.3%)

1,819,643

32,028 (13.3%)

6296.1

5.09 (5.03–5.14)

1,806,936 (33.3%)

13,661,030

97,263 (11.2%)

45,017.2

2.16 (2.15–2.17)

 60–79

3,585,461 (48.7%)

2,719,691

111,548 (46.2%)

43,170.3

2.58 (2.57–2.60)

2,606,293 (48.0%)

16,492,660

514,259 (59.5%)

260,950.5

1.97 (1.97–1.98)

 80+

1,011,112 (13.7%)

634,352

90,052 (37.3%)

53,214.1

1.69 (1.68–1.70)

554,505 (10.2%)

2,162,857

240,433 (27.8%)

168,882.4

1.42 (1.42–1.43)

Sex

 Female

3,717,559 (50.5%)

2,872,180

101,161 (41.9%)

44,397.1

2.28 (2.26–2.29)

2,794,614 (51.5%)

19,176,433

377,760 (43.7%)

194,247.3

1.94 (1.94–1.95)

 Male

3,648,670 (49.5%)

2,752,647

140,414 (58.1%)

58,708.5

2.39 (2.38–2.40)

2,630,558 (48.5%)

17,020,437

487,215 (56.3%)

284,266.0

1.71 (1.71–1.72)

Race

 White

6,068,860 (82.4%)

4,653,123

194,848 (80.7%)

88,602.2

2.20 (2.19–2.21)

4,503,707 (83.0%)

30,498,046

738,242 (85.3%)

410,790.0

1.80 (1.79–1.80)

 Black

771,611 (10.5%)

574,467

32,978 (13.7%)

10,606.9

3.11 (3.08–3.14)

542,333 (10.0%)

3,238,518

85,172 (9.8%)

50,241.0

1.70 (1.68–1.71)

 AI/AN

40,833 (0.6%)

30,360

1310 (0.5%)

342.7

3.82 (3.62–4.03)

28,634 (0.5%)

179,376

3894 (0.5%)

1535.6

2.54 (2.46–2.62)

 API

484,925 (6.6%)

366,878

12,439 (5.1%)

3553.8

3.50 (3.44–3.56)

350,498 (6.5%)

2,280,930

37,667 (4.4%)

15,946.8

2.36 (2.34–2.39)

Year of diagnosis

 1990–1999

1,319,905 (17.9%)

1,019,773

55,329 (22.9%)

22,522.2

2.46 (2.44–2.48)

998,514 (18.4%)

11,120,394

323,784 (37.4%)

149,161.2

2.17 (2.16–2.18)

 2000–2009

3,422,077 (46.5%)

2,687,274

112,518 (46.6%)

49,977.6

2.25 (2.24–2.26)

2,675,604 (49.3%)

20,562,263

457,002 (52.8%)

268,827.0

1.70 (1.70–1.70)

 2010–2016

2,624,247 (35.6%)

1,917,780

73,728 (30.5%)

30,605.8

2.41 (2.39–2.43)

1,751,054 (32.3%)

4,514,212

84,189 (9.7%)

60,525.2

1.39 (1.38–1.40)

Marital status

 Married

4,022,510 (54.6%)

3,173,567

96,497 (39.9%)

50,042.2

1.93 (1.92–1.94)

3,107,029 (57.3%)

21,986,915

441,489 (51.0%)

266,531.8

1.66 (1.65–1.66)

 Unmarried

2,788,366 (37.9%)

2,013,382

129,163 (53.5%)

44,251.0

2.92 (2.90–2.93)

1,881,706 (34.7%)

11,414,836

352,443 (40.7%)

169,938.6

2.07 (2.07–2.08)

 Unknown

555,353 (7.5%)

437,878

15,915 (6.6%)

8812.4

1.81 (1.78–1.83)

436,437 (8.0%)

2,795,119

71,043 (8.2%)

42,042.9

1.69 (1.68–1.70)

Stage

 In situ

451,459 (6.1%)

405,558

4425 (1.8%)

5442.4

0.81 (0.79–0.84)

436,799 (8.1%)

3,550,928

57,379 (6.6%)

35,976.8

1.59 (1.58–1.61)

 Localized

2,838,911 (38.5%)

2,505,010

57,978 (24.0%)

45,487.3

1.27 (1.26–1.29)

2,656,038 (49.0%)

19,930,354

463,751 (53.6%)

276,381.0

1.68 (1.67–1.68)

 Regional

1,189,160 (16.1%)

961,350

40,351 (16.7%)

16,393.8

2.46 (2.44–2.49)

937,482 (17.3%)

5,515,953

127,670 (14.8%)

62,437.5

2.04 (2.03–2.06)

 Distant

1,294,149 (17.6%)

732,298

56,706 (23.5%)

13,720.3

4.13 (4.10–4.17)

566,503 (10.4%)

2,055,188

52,578 (6.1%)

25,174.3

2.09 (2.07–2.11)

 Unstaged

1,592,550 (21.6%)

1,020,611

82,115 (34.0%)

22,061.8

3.72 (3.70–3.75)

828,350 (15.3%)

5,144,448

163,597 (18.9%)

78,543.8

2.08 (2.07–2.09)

Surgery

 Yes

4,373,773 (59.4%)

3,717,285

79,762 (33.0%)

57,493.4

1.39 (1.38–1.40)

3,783,143 (69.7%)

27,669,481

563,877 (65.2%)

320,575.3

1.76 (1.75–1.76)

 No

2,926,045 (39.7%)

1,862,953

159,261 (65.9%)

44,599.3

3.57 (3.55–3.59)

1,602,190 (29.5%)

8,330,829

294,677 (34.1%)

154,778.2

1.90 (1.90–1.91)

 Unknown

66,411 (0.9%)

44,589

2552 (1.1%)

1012.8

2.52 (2.42–2.62)

39,839 (0.7%)

196,560

6421 (0.7%)

3159.9

2.03 (1.98–2.08)

Chemotherapy

 Yes

1,947,887 (26.4%)

1,511,435

40,799 (16.9%)

16,992.5

2.40 (2.38–2.42)

1,361,418 (25.1%)

7,262,809

110,938 (12.8%)

53,628.9

2.07 (2.06–2.08)

 No/Unknown

5,418,342 (73.6%)

4,113,392

200,776 (83.1%)

86,113.1

2.33 (2.32–2.34)

4,063,754 (74.9%)

28,934,062

754,037 (87.2%)

424,884.5

1.77 (1.77–1.78)

Radiotherapy

 Yes

2,021,621 (27.4%)

1,635,770

32,758 (13.6%)

22,878.1

1.43 (1.42–1.45)

1,568,122 (28.9%)

10,489,447

206,859 (23.9%)

118,384.9

1.75 (1.74–1.75)

 No/unknown

5,344,608 (72.6%)

3,989,058

208,817 (86.4%)

80,227.5

2.60 (2.59–2.61)

3,857,050 (71.1%)

25,707,423

658,116 (76.1%)

360,128.5

1.83 (1.82–1.83)

  1. Abbreviations: SMR: standardized mortality ratios; CI, confidence interval; AI/AN: American Indian/Alaska Native; API: Asian or Pacific Islander
  2. a For the categories of age, sex, race and year of diagnosis, the SMR reference population was the specific category in the US subpopulation from 1990 through 2015. For the other variables, the SMR reference population was the entire US population from 1990 through 2015