Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: In vivo assessment of prostate cancer response using quantitative ultrasound characterization of ultrasonic scattering properties

Fig. 4

Representative dot plot for AAC and cell death. Correlation between changes in AAC and cell death fraction from TUNEL staining. Scatter plots of cell death fraction versus changes in AAC from all treatment groups. Apoptotic cell death percentile (brown area) was quantified from TUNEL images. We observed an increase in cell death as a function of HT duration for each combination of the treatment group. Increases in AAC due to cell deaths may have been caused by nuclear fragmentation and filling of the extracellular space with cell debris as tumour cells were treated with a combination of treatments of US-mediated vascular disruption and HT. Regression analysis of cell death fraction versus changes in AAC showed a strong correlation (r2 = 0.62). The best quadratic curve-fitting to the data is shown in blue, with the goodness-of-fit function shown in the inset legend

Back to article page