Table 4 Univariate and multivariate analysis of CRC-specific mortality with in 1,3 and 5 years since diagnosis during (2009–2017) a
Characteristics | Total | Univariate | Multivariate | ||
|---|---|---|---|---|---|
N | baHR | 95% CI | aHR | 95% CI | |
Diagnosis period | |||||
2009–2011 | 288 | – | – | – | |
2012–2014 | 395 | 0.99 | (0.74,1.31) | 0.91 | (0.67, 1.24) |
2015–2017 | 329 | 0.96 | (0.69,1.34) | 0.76 | (0.52, 1.12) |
Age | |||||
< =40 | 40 | 1.87 | (1.09,3.47) | 1.72 | (0.49, 6.07) |
41–50 | 68 | 1.03 | (0.58,1.54) | 0.73 | (0.25, 2.13) |
51–60 | 186 | 1.02 | (0.67,1.54) | 0.79 | (0.39, 1.59) |
61–70 | 288 | – | – | – | – |
71–80 | 237 | 1.53 | (1.09.3.5) | 1.29 | (0.72, 2.35) |
> =81 | 193 | 2.51 | (1.8, 3.5) | 1.36 | (0.65, 2.84) |
Gender | |||||
Female | 430 | 1.2 | (0.92,1.48) | 1.002 | (0.77, 1.31) |
Male | 582 | – | – | ||
Marital status | |||||
Single | 55 | 0.91 | (0.51,1.63) | 0.86 | (0.45, 1.61) |
Married | 748 | – | – | – | – |
Widowed/divorced | 57 | 1.41 | (0.86,2.31) | 1.04 | (0.6, 1.81) |
Unknown | 142 | 0.91 | (.068,1.43) | 0.92 | (0.62, 1.36) |
Nationality | |||||
Non-Saudi | 76 | 0.66 | (0.37,1.18) | 0.65 | (0.35, 1.19) |
Saudi | 936 | – | – | – | – |
Tumor Site | |||||
Right colon | 184 | – | – | – | – |
Left colon | 434 | 0.77 | (0.54,1.11) | 0.72 | (0.49, 1.04) |
Colon-non specified | 160 | 1.12 | (0.76, 1.62) | 0.88 | (0.58, 1.34) |
Rectum | 234 | 1.01 | (0.68, 1.51) | 0.98 | (0.63, 1.54) |
Tumor grade | |||||
Well differentiated | 33 | – | – | – | – |
Moderately differentiated | 774 | 0.73 | (0.38, 1.37) | 0.76 | (0.38, 1.49) |
(Poorly differentiated/Anaplastic)) | 67 | 1.98 | (0.95, 4.11) | 1.52 | (0.69, 3.31) |
Unknown | 138 | 1.7 | (0.86, 3.33) | 1.08 | (0.51, 2.75) |
Stage at diagnosis | |||||
Localized | 186 | – | – | – | – |
Regional | 362 | 1.89 | (1.17,3.04) | 2.51 | (2.51, 4.13) |
Distant metastasis | 225 | 9.01 | (5.79,14.71) | 11.43 | (7.04, 18.55) |
Unknown | 76 | 5.51 | (2.71,11.49) | 4.87 | (2.28, 10.37) |
Basis of diagnosis | |||||
Histology of primary | 972 | – | – | – | – |
Histology of metastases | 28 | 4.89 | (2.98, 8.04) | 1.67 | (0.92, 3.04) |
Others | 12 | 6.42 | (3.45,11.78) | 7.17 | (0.92, 3.04) |
Morphology | |||||
Adenocarcinoma (AC), NOS | 854 | – | – | – | – |
Mucinous AC | 63 | 1.07 | (0.64,1.78) | 0.78 | (0.45, 1.36) |
Mucin-producing AC | 12 | 1.62 | (0.66,3.93) | 1.58 | (0.63, 3.94) |
Signet ring cell carcinoma | 14 | 5.07 | (2.59,9.91) | 1.65 | (0.75, 3.61) |
AC in villous/tubuvillous adenoma | 16 | 0.071 | (0.22,2.21) | 0.96 | (0.30, 3.08) |
Others | 53 | 1.68 | (1.08,2.61) | 0.62 | (0.33, 1.21) |
Surgery | |||||
Yes | 426 | – | – | – | – |
No | 586 | 2.48 | (1.92,3.19) | 1.36 | (1.007,1.83) |
Chemotherapy | |||||
Yes | 411 | – | – | – | – |
No | 601 | 1.39 | (1.07,1.74) | 1.65 | (1.17, 2.33) |
Radiotherapy | |||||
Yes | 95 | – | – | – | – |
No | 917 | 1.26 | (0.82, 1.93) | 0.79 | (0.49, 1.31) |