Table 1 Grades assigned for each of the 48 cases in the study by each of the three pathologists. Grades were assigned on three occasions, separated by a washout period. Each of the grading sessions were completed on either digital pathology screen (once) or on glass slide (two separate sessions). Both the 1973 (grade 1, 2, 3) and 2004 (PUNLMP, low, high) WHO grading systems were applied for each case in all sessions. Pathologists were blinded throughout the study to the results of the original report, to the grades they gave at previous assessment sessions within the study, and to the grades given by the other pathologists in the study. Discrepancies between the digital reporting and first glass reporting are highlighted in red

1

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

2

L

2

L

2

L

2

L

2

L

2

H

2

L

2

L

2

L

2

3

L

2

L

2

L

2

L

2

L

2

H

2

L

2

L

2

H

2

4

H

3

H

3

H

3

H

2

H

2

H

2

H

2

H

2

H

3

5

L

1

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

6

H

2

H

3

H

3

L

2

L

2

H

2

L

2

H

2

H

2

7

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

8

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

9

L

2

L

2

L

2

L

2

H

2

H

3

L

2

L

2

H

2

10

L

2

H

2

L

2

L

1

L

1

L

2

L

2

L

2

L

2

11

H

3

H

3

H

2

H

2

H

2

H

3

H

3

H

3

H

2

12

H

2

L

2

L

2

L

2

H

2

H

2

H

2

H

2

L

2

13

H

3

H

3

H

3

H

2

H

2

H

2

H

3

H

3

H

3

14

L

2

L

2

L

2

L

2

L

2

L

2

L

2

H

2

L

2

15

L

2

L

2

L

2

L

2

L

2

L

1

L

2

L

2

L

2

16

L

2

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

17

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

18

H

3

H

3

H

3

H

2

H

3

H

3

H

3

H

3

H

3

19

H

2

H

2

L

2

L

2

L

2

L

2

H

2

L

2

L

2

20

L

2

L

2

L

2

L

2

L

2

L

2

L

2

H

2

L

2

21

H

2

L

2

L

2

L

2

L

2

L

2

H

2

L

2

L

2

22

H

2

H

2

L

2

L

2

L

2

L

2

H

2

L

2

L

2

23

L

2

L

2

L

1

L

2

L

2

L

2

L

2

L

2

L

2

24

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

25

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

26

H

3

L

2

H

3

H

3

H

2

H

3

H

3

H

3

H

3

27

L

1

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

28

H

3

H

3

L

2

H

2

H

2

H

2

H

2

L

2

H

2

29

H

2

H

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

30

L

2

L

2

L

1

L

2

L

2

L

2

L

2

L

2

H

2

31

H

3

H

3

H

2

L

2

L

2

L

2

H

2

H

3

H

3

32

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

33

PUNLMP

N/A

PUNLMP

N/A

PUNLMP

N/A

L

2

L

2

L

2

L

2

L

2

L

2

34

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

35

H

3

H

3

L

2

H

2

H

2

H

3

L

2

H

2

H

2

36

H

3

H

3

H

3

H

3

H

3

H

3

H

2

H

3

H

2

37

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

38

H

3

H

3

H

3

H

3

H

2

H

3

H

3

H

3

H

2

39

L

2

L

2

L

2

H

2

L

2

L

2

L

2

H

2

H

2

40

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

L

2

41

L

2

H

2

PUNLMP

N/A

L

2

L

2

L

2

L

2

L

2

L

2

42

PUNLMP

N/A

PUNLMP

N/A

PUNLMP

N/A

L

2

L

2

L

2

L

2

L

2

L

2

43

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

44

H

3

H

3

H

2

L

2

H

2

H

3

L

2

H

2

H

2

45

H

3

H

3

H

3

H

2

H

2

H

3

L

2

H

3

H

3

46

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

H

3

47

H

3

H

2

H

3

H

2

H

2

H

3

H

2

H

3

H

3

48

H

2

H

3

L

2

L

2

L

2

H

2

L

2

L

2

L

2