Skip to main content

Table 1 Demographic, perioperative laboratory results, genetic, and postoperative treatment-related data

From: Prognostic significance of the postoperative prognostic nutritional index in patients with glioblastoma: a retrospective study

  Preoperative PNI Postoperative PNI
Low (PNI < 50. 1) (n = 173) High (PNI ≥ 50. 1) (n = 162) P value Low (PNI < 50. 2) (n = 206) High (PNI ≥ 50. 2) (n = 129) P value
Age (yr) 56.5 ± 13.9 52.3 ± 13.7 0.005 57.2 ± 13.9 50.1 ± 12.9 <  0.001
<  60 96 (55.5%) 108 (66.7%) 0.047 108 (52.4%) 96 (74.4%) <  0.001
< 70 136 (78.6%) 148 (91.4%) 0.002 161 (78.2%) 123 (95.3%) <  0.001
Male gender (n) 91 (52.6%) 104 (64.2%) 0.041 114 (55.3%) 81 (62.8%) 0.218
BMI (kg/m2) 22.6 ± 3.2 23.5 ± 3.2 0.019 22.7 ± 3.2 23.6 ± 3.1 0.021
ASA physical status (n)    0.116    0.235
 I 57 (32.9%) 63 (38.9%)   69 (33.5%) 51 (39.5%)  
 II 93 (53.8%) 88 (54.3%)   112 (54.4%) 69 (53.5%)  
 III 23 (13.3%) 11 (6.8%)   25 (12.1%) 9 (7.0%)  
Comorbidity (n)
 Hypertension 45 (26.0%) 46 (28.4%) 0.713 58 (28.2%) 33 (25.6%) 0.697
 Diabetes mellitus 16 (9.2%) 9 (5.6%) 0.281 16 (7.8%) 9 (7.0%) 0.957
 Cardiac disease 13 (7.5%) 6 (3.7%) 0.204 16 (7.8%) 3 (2.3%) 0.050
 Respiratory disease 7 (4.0%) 4 (2.5%) 0.544 11 (5.3%) 0 (0.0%) 0.008
 Liver disease 9 (5.2%) 8 (4.9%) 1.000 11 (5.3%) 6 (4.7%) 0.981
 Renal disease 3 (1.7%) 0 (0.0%) 0.249 3 (1.5%) 0 (0.0%) 0.287
 Cerebrovascular disease 12 (6.9%) 6 (3.7%) 0.285 10 (4.9%) 8 (6.2%) 0.777
 Extracranial malignancy 11 (6.4%) 4 (2.5%) 0.113 12 (5.8%) 3 (2.3%) 0.177
Daily activity
 Preoperative KPS score 80 (70–90) 90 (80–90) 0.009 85 (70–90) 90 (80–90) 0.023
  ≥ 70 (n) 144 (83.2%) 154 (95.1%) 0.001 177 (85.9%) 121 (93.8%) 0.040
 KPS score at hospital discharge 90 (70–90) 90 (80–90) 0.024 90 (70–90) 90 (80–90) <  0.001
  ≥ 70 (n) 145 (83.8%) 146 (90.1%) 0.122 166 (80.6%) 125 (96.9%) <  0.001
Laboratory findings
 Albumin (g/dL)
  Preoperative 3.9 ± 0.4 4.4 ± 0.3 <  0.001 4.1 ± 0.4 4.3 ± 0.4 <  0.001
  Postoperative 3.9 ± 0.4 4.1 ± 0.3 <  0.001 3.8 ± 0.4 4.3 ± 0.2 <  0.001
  Delta (preoperative – postoperative) −0.01 ± 0.49 −0.26 ± 0.38 <  0.001 −0.23 ± 0.49 0.03 ± 0.35 <  0.001
Lymphocyte count (106/L)
 Preoperative 1280.8 ± 495.2 2064.3 ± 667.6 <  0.001 1521.9 ± 646.7 1879.6 ± 736.3 <  0.001
  < 1500 (n) 127 (73.4%) 37 (22.8%) <  0.001 116 (56.3%) 48 (37.2%) 0.001
 Postoperative 1558.5 ± 646.7 1827.0 ± 578.6 <  0.001 1422.4 ± 466.5 2113.1 ± 621.4 <  0.001
  < 1500 (n) 89 (51.4%) 47 (29.0%) <  0.001 120 (58.3%) 16 (12.4%) <  0.001
 Delta (preoperative – postoperative) − 277.8 ± 680.1 237.3 ± 755.2 <  0.001 99.5 ± 702.4 −233.4 ± 808.5 <  0.001
PNI
 Preoperative 45.5 ± 3.6 54.4 ± 3.2 <  0.001 48.2 ± 5.2 52.4 ± 5.3 <  0.001
 Postoperative 46.8 ± 5.2 50.6 ± 5.1 <  0.001 45.4 ± 4.0 53.8 ± 3.0 <  0.001
 Delta (preoperative – postoperative) −1.3 ± 5.8 3.8 ± 5.2 <  0.001 2.8 ± 5.9 −1.4 ± 5.3 <  0.001
Surgery time (hr) 4.4 ± 1.3 4.5 ± 1.4 0.581 4.4 ± 1.4 4.5 ± 1.2 0.471
Intraoperative transfusion (n) 41 (23.7%) 25 (15.4%) 0.077 54 (26.2%) 12 (9.3%) <  0.001
Tumor resection (n)    0.642    0.072
 Gross total 102 (59.0%) 107 (66.0%) 0.220 119 (57.8%) 90 (69.8%) 0.037
 Near total 24 (13.9%) 16 (9.9%) 0.338 24 (11.7%) 16 (12.4%) 0.973
 Subtotal 32 (18.5%) 28 (17.3%) 0.883 42 (20.4%) 18 (14.0%) 0.178
 Partial 8 (4.6%) 7 (4.3%) 1.000 11 (5.3%) 4 (3.1%) 0.422
 Biopsy 7 (4.0%) 4 (2.5%) 0.544 10 (4.9%) 1 (0.8%) 0.056
Gene expression profiles (n)
 MGMT Promoter methylation* 97 (56.4%) 80 (50.0%) 0.291 110 (54.2%) 67 (51.9%) 0.774
 EGFR amplification 45 (26.0%) 41 (25.6%) 1.000 53 (25.9%) 33 (25.8%) 1.000
 IDH mutation 19 (12.2%) 30 (19.6%) 0.103 27 (14.4%) 22 (18.0%) 0.493
Postoperative new neurologic deficit (n) 43 (24.9%) 24 (14.8%) 0.031 54 (26.2%) 13 (10.1%) <  0.001
Postoperative treatment (n)    0.033    0.030
 Stupp protocol 151 (87.3%) 151 (93.2%) 0.102 180 (87.4%) 122 (94.6%) 0.050
 Completed 99 (57.2%) 104 (64.2%) 0.219 113 (54.9%) 90 (69.8%) 0.009
 Chemotherapy 6 (3.5%) 5 (3.1%) 1.000 7 (3.4%) 4 (3.1%) 1.000
 Radiotherapy 1 (0.6%) 3 (1.9%) 0.357 2 (1.0%) 2 (1.6%) 0.641
 None 15 (8.7%) 3 (1.9%) 0.007 17 (8.3%) 1 (0.8%) 0.002
  1. Data are expressed as number (proportion), mean ± standard deviation, or median (interquartile range). BMI body mass index, ASA American Society of Anesthesiologists, KPS Karnofsky performance status, delta; preoperative –postoperative, PNI prognostic nutritional index, MGMT O6-methylguanine-DNA methyltransferase, EGFR epidermal growth factor receptor, IDH isocitrate dehydrogenase. Data are expressed as number (proportion), mean ± standard deviation, or median (interquartile range). *: n = 172 in preoperative PNI low group, n = 160 in preoperative PNI high group, and n = 203 in postoperative PNI low group. †: n = 160 in preoperative PNI high group, and n = 205 in postoperative PNI low group, and n = 128 in postoperative PNI high group. : n = 156 in preoperative PNI low group, n = 153 in preoperative PNI high group, and n = 187 in postoperative PNI low group, and n = 122 in postoperative PNI high group