Table 2 Single protein analysis for CA125, OPN, HE4, leptin, prolactin and MIF. Area under the curve (AUC) with 95% confidence interval (CI) and median expression plus interquartile range (IQR) of each protein biomarker in both the benign and malignant group are presented in the following table
Protein biomarker | AUC | with 95% CI | Median (IQR) expression / benign collective | Median (IQR) expression / malignant collective |
|---|---|---|---|---|
CA125 | 0.929 | (0.813–1.00) | 9.02 U/ml (12.37) | 348.96 U/ml (1053.90) |
OPN | 0.907 | (0.804–0.98) | 24,522.95 pg/ml (7934.32) | 45,584.27 pg/ml (13,899.48) |
HE4 | 0.796 | (0.682–0.917) | 0.00 pg/ml (0.00) | 7349.02 pg/ml (22,947.18) |
Leptin | 0.744 | (0.582–0.896) | 17,867.52 pg/ml (20,264.12) | 6025.32 pg/ml (11,297.58) |
Prolactin | 0.587 | (0.404–0.762) | 20,948.71 pg/ml (27,611.91) | 17,912.65 pg/ml (23,332.14) |
MIF | 0.567 | (0.382–0.742) | 219.12 pg/ml (204.46) | 262.59 pg/ml (429.09) |