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Fig. 4 | BMC Cancer

Fig. 4

From: Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

Fig. 4

miR-214 was key for hypoxia-induced tumorigenesis of CRC. A StarBase 2.0 predicted the interaction between circEIF3K and miR-214. B miR-214 levels were examined by RT-qPCR in HCT116 cells stably transfected with sh-NC or sh-circEIF3K-1. ***p < 0.001. C miR-214 expression levels were detected by RT-qPCR in HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic. ***p < 0.001. D and E Cell proliferation of HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic were examined by cell colony formation assay. ***p < 0.001. F and G Invasion of HCT116 cells treated with mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic were measured by transwell assay. ***p < 0.001. H and I Tube lengths of HDLEC cells (mock-CM, hypoxia-CM, hypoxia-CM + miR-214 mimic) were measured by tube formation assay. ***p < 0.001

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