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Fig. 2 | BMC Cancer

Fig. 2

From: Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis

Fig. 2

circEIF3K depletion in CAF led to attenuated CRC progression. A circEIF3K expression levels were shown in CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by RT-qPCR. ***p < 0.001. B and C Cell proliferation of HCT116 or SW620 cells incubated with CM of CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by cell colony formation assay under hypoxia. ***p < 0.001. D and E The invasion of HCT116 or SW620 cells incubated with CM of CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 were determined by transwell assay under hypoxia. ***p < 0.001. F and G Tube lengths of HDLEC cells (sh-NC-CM, sh-circEIF3K-1-CM, sh-circEIF3K-2-CM) were measured by tube formation assay under hypoxia. ***p < 0.001. H and I Cell proliferation of HCT116 or SW620 cells incubated with exosomes derived from CAFs stably transfected with sh-NC, sh-circEIF3K-1, sh-circEIF3K-2 by cell colony formation assay under hypoxia. ***p < 0.001

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