Table 1 Patient characteristics
Characteristics | NSCLC n = 96 n, (%) | HNC/GC n = 92 n, (%) | P-value |
|---|---|---|---|
Age, years | |||
 Median (range) | 68 (44–80) | 67 (24–85) | 0.46 |
  < 65 | 33 (34.4) | 38 (41.3) |  |
  ≥ 65 | 63 (65.6) | 54 (58.7) |  |
Sex | 0.98 | ||
 Male | 68 (70.8) | 65 (70.7) |  |
 Female | 28 (29.2) | 27 (29.3) |  |
Smoking status | 0.40 | ||
 Current/ex-smoker | 75 (78.1) | 67 (72.8) |  |
 Current smoker | 5 (5.2) | 11 (12.0) |  |
 Ex-smoker | 70 (72.9) | 56 (60.9) |  |
  < 20 pack-years | 12 (12.5) | 18 (19.6) |  |
  ≥ 20 pack-years | 63 (65.6) | 45 (48.9) |  |
 Unknown pack-years | 0 | 4 (4.3) |  |
 Never-smoker | 21 (21.9) | 25 (27.2) |  |
Performance status | 0.36 | ||
 0–1 | 82 (85.4) | 74 (80.4) |  |
  ≥ 2 | 14 (14.6) | 18 (19.6) |  |
Prevalence of patient comorbidities | |||
 Arterial hypertension | 30 (31.3) | 26 (28.3) | 0.65 |
 Cardiovascular disease | 5 (5.2) | 8 (8.7) | 0.35 |
 Diabetes | 11 (11.5) | 12 (13.0) | 0.74 |
 COPD | 12 (12.5) | 3 (3.3) | 0.029a |
No. of treatment cycles of nivolumab | |||
 Median (range) | 5 (1–58) | 5 (1–25) | 0.42 |
 Pre-existing ILD on chest CT | |||
 Normal | 70 (72.9) | 78 (84.8) | 0.047 |
 Pre-existing ILD | 26 (27.1) | 14 (15.2) |  |
 UIP | 6 (6.3) | 2 (2.2) |  |
 Possible UIP | 3 (3.1) | 1 (1.1) |  |
 Inconsistent with UIP | 17 (17.7) | 11 (12.0) |  |