Table 6 Comparison of cellular factors levels between the co-infection and mono-infection groups
From: Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer
Cellular Factors | Co-infected PCa (a) vs not co-infected PCa (b) | Co-infected Positive control (c) vs not co-infected control (d) | Co-infected PCa (a) vs HPV-mono-infected PCa (e) | Co-infected PCa (a) vs EBV-mono-infected PCa (f) | Co-infected PCa (a) and non-HPV/non-EBV PCa (g) |
|---|---|---|---|---|---|
NF-κB | a: 26.9 ± 3.1 | c: 21.6 ± 2.5 | a: 26.9 ± 3.1 | a: 26.9 ± 3.1 | a: 26.9 ± 3.1 |
b: 17.8 ± 7.1 | d: 8.2 ± 6 | e: 20.3 ± 7.2 | f: 18.4 ± 3.2 | g: 12 ± 8 | |
P* (0.0004) | P+ (0.004) | P$ (ns) | P^ (ns) | P# (0.0001) | |
TNF-α | a: 25.5 ± 2.7 | c: 19.5 ± 3.1 | a: 25.5 ± 2.7 | a: 25.5 ± 2.7 | a: 25.5 ± 2.7 |
b: 15.2 ± 6.8 | d: 10.6 ± 6.3 | e: 19 ± 7.6 | f: 16.2 ± 4.8 | g: 10.2 ± 6.3 | |
P* (0.001) | P+ (ns) | P$ (ns) | P^ (0.04) | P# (0.0001) | |
IL-1 | a: 18.4 ± 3.6 | c: 18.3 ± 3.5 | a: 18.4 ± 3.6 | a: 18.4 ± 3.6 | a: 18.4 ± 3.6 |
b: 14.2 ± 4.4 | d: 6.7 ± 4.2 | e: 16.1 ± 4.6 | f: 12.5 ± 4.2 | g: 7.1 ± 4 | |
P* (ns) | P+ (0.004) | P$ (ns) | P^ (ns) | P# (0.0001) | |
IL-6 | a: 21.3 ± 2.1 | c: 19 ± 3.9 | a: 21.3 ± 2.1 | a: 21.3 ± 2.1 | a: 21.3 ± 2.1 |
b:12.2 ± 5.2 | d: 7.5 ± 5.6 | e: 16.3 ± 6.5 | f: 13.3 ± 5.2 | g: 8.2 ± 1.6 | |
P* (0.004) | P+ (0.003) | P$ (ns) | P^ (ns) | P# (0.001) | |
IL-8 | a: 17.3 ± 4.9 | c: 16.3 ± 3.2 | a: 17.3 ± 4.9 | a: 17.3 ± 4.9 | a: 17.3 ± 4.9 |
b: 11.6 ± 6.1 | d: 4.5 ± 3.8 | e: 18.2 ± 6.1 | f: 4.8 ± 3.9 | g: 9.1 ± 3.6 | |
P* (ns) | P+ (0.009) | P$ (ns) | P^ (0.01) | P# (ns) | |
IL-11 | a: 21.8 ± 6.4 | c: 17 ± 5 | a: 21.8 ± 6.4 | a: 21.8 ± 6.4 | a: 21.8 ± 6.4 |
b: 14.3 ± 8.1 | d: 6.1 ± 5.4 | e: 20.6 ± 8.2 | f: 14.3 ± 8.1 | g: 10.7 ± 5.9 | |
P* (ns) | P+ (ns) | P$ (ns) | P^ (ns) | P# (0.04) | |
IL-17 | a: 15.2 ± 1.8 | c: 13 ± 2 | a: 15.2 ± 1.8 | a: 15.2 ± 1.8 | a: 15.2 ± 1.8 |
b: 8.7 ± 3.3 | d: 3.4 ± 2.7 | e: 13.2 ± 2.4 | f: 8 ± 2.7 | g: 7.3 ± 2.4 | |
P* (0.008) | P+ (0.002) | P$ (ns) | P^ (0.006) | P# (0.003) | |
VEGF | a: 53.6 ± 3.8 | c: 29.6 ± 1.5 | a: 53.6 ± 3.8 | a: 53.6 ± 3.8 | a: 53.6 ± 3.8 |
b: 38.7 ± 7.3 | d: 12.5 ± 4.8 | e: 51.44 ± 3 | f: 35.8 ± 4.7 | g: 35.8 ± 3.6 | |
P* (0.04) | P+ (ns) | P$ (ns) | P^ (0.02) | P# (0.02) | |
TGF-β | a: 21.5 ± 4.5 | c: 16 ± 2 | a: 21.5 ± 4.5 | a: 21.5 ± 4.5 | a: 21.5 ± 4.5 |
b: 13.9 ± 7.5 | d: 6.6 ± 4.5 | e: 18.2 ± 7.3 | f: 13.3 ± 3.5 | g: 11 ± 5.6 | |
P* (ns) | P+ (ns) | P$ (ns) | P^ (0.03) | P# (0.01) | |
Rb | a: 2.3 ± 1 | c: 1.6 ± 1.1 | a: 2.3 ± 1 | a: 2.3 ± 1 | a: 2.3 ± 1 |
b: 10.5 ± 5.3 | d: 15.3 ± 5.2 | e: 2.7 ± 0.9 | f: 12.4 ± 4.7 | g: 12.3 ± 3.3 | |
P* (< 0.0001) | P+ (< 0.0001) | P$ (ns) | P^ (< 0.0001) | P# (< 0.0001) | |
P53 | a: 2.6 ± 0.9 | c: 2.3 ± 0.5 | a: 2.6 ± 0.9 | a: 2.6 ± 0.9 | a: 2.6 ± 0.9 |
b: 12.1 ± 6.2 | d: 15.1 ± 5.7 | e: 3.7 ± 1.4 | f: 13.3 ± 5.4 | g: 14.9 ± 5 | |
P* (< 0.0001) | P+ (0.0006) | P$ (ns) | P^ (< 0.0001) | P# (< 0.0001) | |
ROS | a: 24.5 ± 5.8 | c: 15.6 ± 3 | a: 24.5 ± 5.8 | a: 24.5 ± 5.8 | a: 24.5 ± 5.8 |
b: 6.6 ± 8 | d: 5.1 ± 4.4 | e: 22.2 ± 5.3 | f: 3.4 ± 1.9 | g: 2.6 ± 2.1 | |
P* (< 0.0001) | P+ (ns) | P$ (ns) | P^ (< 0.0001) | P# (< 0.0001) | |
RNS | a: 20 ± 9.4 | c: 17.3 ± 3.2 | a: 20 ± 9.4 | a: 20 ± 9.4 | a: 20 ± 9.4 |
b: 10.1 ± 9.7 | d: 4 ± 3.7 | e: 20.4 ± 10.6 | f: 9.2 ± 9.3 | g: 5.6 ± 4.3 | |
P* (0.02) | P+ (0.01) | P$ (ns) | P^ (0.02) | P# (0.004) | |
Survivin | a: 22.5 ± 1 | c: 21.3 ± 0.5 | a: 22.5 ± 1 | a: 22.5 ± 1 | a: 22.5 ± 1 |
b: 13.7 ± 4.9 | d: 7.4 ± 4 | e: 19.5 ± 1.8 | f: 17.2 ± 4.3 | g: 12.3 ± 4.7 | |
P* (< 0.0001) | P+ (< 0.0001) | P$ (ns) | P^ (ns) | P# (< 0.0001) | |
Bcl-2 | a: 14.1 ± 1.2 | c: 15.4 ± 1.3 | a: 14.1 ± 1.2 | a: 14.1 ± 1.2 | a: 14.1 ± 1.2 |
b: 8.8 ± 3 | d: 5 ± 2.6 | e: 13.5 ± 1 | f: 8 ± 2.1 | g: 7.2 ± 1.9 | |
P* (0.005) | P+ (0.0004) | P$ (ns) | P^ (0.005) | P# (0.001) | |
CD44 | a: 10.6 ± 5.4 | c: 9.3 ± 1.5 | a: 10.6 ± 5.4 | a: 10.6 ± 5.4 | a: 10.6 ± 5.4 |
b: 7.2 ± 4.8 | d: 3.5 ± 1.7 | e: 3.7 ± 1.4 | f: 10.8 ± 4.4 | g: 3.9 ± 2 | |
P* (ns) | P+ (ns) | P$ (0.03) | P^ (ns) | P# (0.01) | |
TWIST | a: 26.8 ± 6.7 | c: 23 ± 2 | a: 26.8 ± 6.7 | a: 26.8 ± 6.7 | a: 26.8 ± 6.7 |
b: 6.8 ± 10.1 | d: 4.6 ± 4.9 | e: 25.6 ± 9.9 | f: 2.5 ± 1.3 | g: 2.3 ± 1.4 | |
P* (< 0.0001) | P+ (0.009) | P$ (ns) | P^ (< 0.0001) | P# (< 0.0001) | |
E-cad | a: 2.7 ± 0.6 | c: 2.6 ± 0.5 | a: 2.7 ± 0.6 | a: 2.7 ± 0.6 | a: 2.7 ± 0.6 |
b: 15.1 ± 7.7 | d: 14.6 ± 4.6 | e: 4.5 ± 3 | f: 18 ± 5.8 | g: 16.8 ± 6.9 | |
P* (< 0.0001) | P+ (0.007) | P$ (ns) | P^ (< 0.0001) | P# (< 0.0001) | |
N-cad | a: 25.9 ± 6.8 | c: 25.3 ± 7.3 | a: 25.9 ± 6.8 | a: 25.9 ± 6.8 | a: 25.9 ± 6.8 |
b: 7.6 ± 9.8 | d: 3.8 ± 5.5 | e: 25.6 ± 9.7 | f: 3.4 ± 1.8 | g: 3.4 ± 2.5 | |
P* (0.001) | P+ (0.02) | P$ (ns) | P^ (0.0004) | P# (0.0003) | |
PTPN13 | a: 6.2 ± 7.6 | c:2 ± 1 | a: 6.2 ± 7.6 | a: 6.2 ± 7.6 | a: 6.2 ± 7.6 |
b: 10.5 ± 5.3 | d: 14.1 ± 5.8 | e: 3.6 ± 3.6 | f: 12.7 ± 4.7 | g: 12.5 ± 4 | |
P* (ns) | P+ (0.002) | P$ (ns) | P^ (0.03) | P# (0.03) | |
SLUG | a: 3.5 ± 1.6 | c: 3.2 ± 1.4 | a: 3.5 ± 1.6 | a: 3.5 ± 1.6 | a: 3.5 ± 1.6 |
b: 1.8 ± 1.8 | d: 0.96 ± 2.8 | e: 4.3 ± 1.1 | f: 0.9 ± 1.4 | g: 1 ± 1.1 | |
P* (ns) | P+ (ns) | P$ (ns) | P^ (0.004) | P# (0.01) |