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Table 6 Comparison of cellular factors levels between the co-infection and mono-infection groups

From: Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

Cellular Factors Co-infected PCa (a) vs not co-infected PCa (b) Co-infected Positive control (c) vs not co-infected control (d) Co-infected PCa (a) vs HPV-mono-infected PCa (e) Co-infected PCa (a) vs EBV-mono-infected PCa (f) Co-infected PCa (a) and non-HPV/non-EBV PCa (g)
NF-κB a: 26.9 ± 3.1 c: 21.6 ± 2.5 a: 26.9 ± 3.1 a: 26.9 ± 3.1 a: 26.9 ± 3.1
b: 17.8 ± 7.1 d: 8.2 ± 6 e: 20.3 ± 7.2 f: 18.4 ± 3.2 g: 12 ± 8
P* (0.0004) P+ (0.004) P$ (ns) P^ (ns) P# (0.0001)
TNF-α a: 25.5 ± 2.7 c: 19.5 ± 3.1 a: 25.5 ± 2.7 a: 25.5 ± 2.7 a: 25.5 ± 2.7
b: 15.2 ± 6.8 d: 10.6 ± 6.3 e: 19 ± 7.6 f: 16.2 ± 4.8 g: 10.2 ± 6.3
P* (0.001) P+ (ns) P$ (ns) P^ (0.04) P# (0.0001)
IL-1 a: 18.4 ± 3.6 c: 18.3 ± 3.5 a: 18.4 ± 3.6 a: 18.4 ± 3.6 a: 18.4 ± 3.6
b: 14.2 ± 4.4 d: 6.7 ± 4.2 e: 16.1 ± 4.6 f: 12.5 ± 4.2 g: 7.1 ± 4
P* (ns) P+ (0.004) P$ (ns) P^ (ns) P# (0.0001)
IL-6 a: 21.3 ± 2.1 c: 19 ± 3.9 a: 21.3 ± 2.1 a: 21.3 ± 2.1 a: 21.3 ± 2.1
b:12.2 ± 5.2 d: 7.5 ± 5.6 e: 16.3 ± 6.5 f: 13.3 ± 5.2 g: 8.2 ± 1.6
P* (0.004) P+ (0.003) P$ (ns) P^ (ns) P# (0.001)
IL-8 a: 17.3 ± 4.9 c: 16.3 ± 3.2 a: 17.3 ± 4.9 a: 17.3 ± 4.9 a: 17.3 ± 4.9
b: 11.6 ± 6.1 d: 4.5 ± 3.8 e: 18.2 ± 6.1 f: 4.8 ± 3.9 g: 9.1 ± 3.6
P* (ns) P+ (0.009) P$ (ns) P^ (0.01) P# (ns)
IL-11 a: 21.8 ± 6.4 c: 17 ± 5 a: 21.8 ± 6.4 a: 21.8 ± 6.4 a: 21.8 ± 6.4
b: 14.3 ± 8.1 d: 6.1 ± 5.4 e: 20.6 ± 8.2 f: 14.3 ± 8.1 g: 10.7 ± 5.9
P* (ns) P+ (ns) P$ (ns) P^ (ns) P# (0.04)
IL-17 a: 15.2 ± 1.8 c: 13 ± 2 a: 15.2 ± 1.8 a: 15.2 ± 1.8 a: 15.2 ± 1.8
b: 8.7 ± 3.3 d: 3.4 ± 2.7 e: 13.2 ± 2.4 f: 8 ± 2.7 g: 7.3 ± 2.4
P* (0.008) P+ (0.002) P$ (ns) P^ (0.006) P# (0.003)
VEGF a: 53.6 ± 3.8 c: 29.6 ± 1.5 a: 53.6 ± 3.8 a: 53.6 ± 3.8 a: 53.6 ± 3.8
b: 38.7 ± 7.3 d: 12.5 ± 4.8 e: 51.44 ± 3 f: 35.8 ± 4.7 g: 35.8 ± 3.6
P* (0.04) P+ (ns) P$ (ns) P^ (0.02) P# (0.02)
TGF-β a: 21.5 ± 4.5 c: 16 ± 2 a: 21.5 ± 4.5 a: 21.5 ± 4.5 a: 21.5 ± 4.5
b: 13.9 ± 7.5 d: 6.6 ± 4.5 e: 18.2 ± 7.3 f: 13.3 ± 3.5 g: 11 ± 5.6
P* (ns) P+ (ns) P$ (ns) P^ (0.03) P# (0.01)
Rb a: 2.3 ± 1 c: 1.6 ± 1.1 a: 2.3 ± 1 a: 2.3 ± 1 a: 2.3 ± 1
b: 10.5 ± 5.3 d: 15.3 ± 5.2 e: 2.7 ± 0.9 f: 12.4 ± 4.7 g: 12.3 ± 3.3
P* (< 0.0001) P+ (< 0.0001) P$ (ns) P^ (< 0.0001) P# (< 0.0001)
P53 a: 2.6 ± 0.9 c: 2.3 ± 0.5 a: 2.6 ± 0.9 a: 2.6 ± 0.9 a: 2.6 ± 0.9
b: 12.1 ± 6.2 d: 15.1 ± 5.7 e: 3.7 ± 1.4 f: 13.3 ± 5.4 g: 14.9 ± 5
P* (< 0.0001) P+ (0.0006) P$ (ns) P^ (< 0.0001) P# (< 0.0001)
ROS a: 24.5 ± 5.8 c: 15.6 ± 3 a: 24.5 ± 5.8 a: 24.5 ± 5.8 a: 24.5 ± 5.8
b: 6.6 ± 8 d: 5.1 ± 4.4 e: 22.2 ± 5.3 f: 3.4 ± 1.9 g: 2.6 ± 2.1
P* (< 0.0001) P+ (ns) P$ (ns) P^ (< 0.0001) P# (< 0.0001)
RNS a: 20 ± 9.4 c: 17.3 ± 3.2 a: 20 ± 9.4 a: 20 ± 9.4 a: 20 ± 9.4
b: 10.1 ± 9.7 d: 4 ± 3.7 e: 20.4 ± 10.6 f: 9.2 ± 9.3 g: 5.6 ± 4.3
P* (0.02) P+ (0.01) P$ (ns) P^ (0.02) P# (0.004)
Survivin a: 22.5 ± 1 c: 21.3 ± 0.5 a: 22.5 ± 1 a: 22.5 ± 1 a: 22.5 ± 1
b: 13.7 ± 4.9 d: 7.4 ± 4 e: 19.5 ± 1.8 f: 17.2 ± 4.3 g: 12.3 ± 4.7
P* (< 0.0001) P+ (< 0.0001) P$ (ns) P^ (ns) P# (< 0.0001)
Bcl-2 a: 14.1 ± 1.2 c: 15.4 ± 1.3 a: 14.1 ± 1.2 a: 14.1 ± 1.2 a: 14.1 ± 1.2
b: 8.8 ± 3 d: 5 ± 2.6 e: 13.5 ± 1 f: 8 ± 2.1 g: 7.2 ± 1.9
P* (0.005) P+ (0.0004) P$ (ns) P^ (0.005) P# (0.001)
CD44 a: 10.6 ± 5.4 c: 9.3 ± 1.5 a: 10.6 ± 5.4 a: 10.6 ± 5.4 a: 10.6 ± 5.4
b: 7.2 ± 4.8 d: 3.5 ± 1.7 e: 3.7 ± 1.4 f: 10.8 ± 4.4 g: 3.9 ± 2
P* (ns) P+ (ns) P$ (0.03) P^ (ns) P# (0.01)
TWIST a: 26.8 ± 6.7 c: 23 ± 2 a: 26.8 ± 6.7 a: 26.8 ± 6.7 a: 26.8 ± 6.7
b: 6.8 ± 10.1 d: 4.6 ± 4.9 e: 25.6 ± 9.9 f: 2.5 ± 1.3 g: 2.3 ± 1.4
P* (< 0.0001) P+ (0.009) P$ (ns) P^ (< 0.0001) P# (< 0.0001)
E-cad a: 2.7 ± 0.6 c: 2.6 ± 0.5 a: 2.7 ± 0.6 a: 2.7 ± 0.6 a: 2.7 ± 0.6
b: 15.1 ± 7.7 d: 14.6 ± 4.6 e: 4.5 ± 3 f: 18 ± 5.8 g: 16.8 ± 6.9
P* (< 0.0001) P+ (0.007) P$ (ns) P^ (< 0.0001) P# (< 0.0001)
N-cad a: 25.9 ± 6.8 c: 25.3 ± 7.3 a: 25.9 ± 6.8 a: 25.9 ± 6.8 a: 25.9 ± 6.8
b: 7.6 ± 9.8 d: 3.8 ± 5.5 e: 25.6 ± 9.7 f: 3.4 ± 1.8 g: 3.4 ± 2.5
P* (0.001) P+ (0.02) P$ (ns) P^ (0.0004) P# (0.0003)
PTPN13 a: 6.2 ± 7.6 c:2 ± 1 a: 6.2 ± 7.6 a: 6.2 ± 7.6 a: 6.2 ± 7.6
b: 10.5 ± 5.3 d: 14.1 ± 5.8 e: 3.6 ± 3.6 f: 12.7 ± 4.7 g: 12.5 ± 4
P* (ns) P+ (0.002) P$ (ns) P^ (0.03) P# (0.03)
SLUG a: 3.5 ± 1.6 c: 3.2 ± 1.4 a: 3.5 ± 1.6 a: 3.5 ± 1.6 a: 3.5 ± 1.6
b: 1.8 ± 1.8 d: 0.96 ± 2.8 e: 4.3 ± 1.1 f: 0.9 ± 1.4 g: 1 ± 1.1
P* (ns) P+ (ns) P$ (ns) P^ (0.004) P# (0.01)
  1. Geometric Mean ± Standard Deviation, *: comparison between group a versus group b, +: comparison between group c versus group d, $: comparison between group e versus group f, ^: $: comparison between group g versus group h, FDR correction for multiple comparisons by Benjamini-Hochberg method