Table 4 Comparison of cellular factors levels between the EBV positive and negative samples
From: Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer
Cellular Factors | PCa group (a) vs control group (b) | EBV-positive samples (c) vs EBV-negative samples (d) | EBV-positive PCa (e) vs EBV-negative PCa (f) | EBV-positive control (g) vs EBV-negative control (h) | P* | P+ | P$ | P^ |
|---|---|---|---|---|---|---|---|---|
NF-κB | a: 19.4 ± 7.4 b: 9.5 ± 7 | c: 18 ± 7.8 d: 12.7 ± 9 | e: 22.4 ± 4.3 f: 15.4 ± 8.8 | g: 10.9 ± 7 h: 7.1 ± 6.6 | < 0.0001 | 0.006 | 0.004 1.45 | ns |
TNF-α | a: 17 ± 7.4 b: 11.7 ± 6.7 | c: 18 ± 5.5 d: 11.03 ± 8.1 | e: 19.7 ± 5.7 f: 13.4 ± 7.9 | g: 15.2 ± 4.1 h: 6 ± 6.4 | 0.002 | < 0.0001 | 0.001 1.47 | 0.001 |
IL-1 | a: 13 ± 5.7 b: 7.8 ± 5.3 | c: 13.1 ± 5.3 d: 8.4 ± 6.1 | e: 15 ± 4.6 f: 10.4 ± 6 | g: 10 ± 4.8 h: 4.2 ± 4 | 0.0002 | 0.001 | 0.01 1.44 | 0.05 |
IL-6 | a: 14.4 ± 6 b: 8.9 ± 6.6 | c: 14.8 ± 5.8 d: 9 ± 6.6 | e: 16.4 ± 5.5 f: 11.8 ± 5.9 | g: 12.3 ± 5.5 h: 3.4 ± 3.9 | 0.0004 | 0.0003 | 0.02 1.3 | 0.004 |
IL-8 | a: 12.62 ± 6.2 b: 5.68 ± 5.1 | c: 10.4 ± 6.6 d: 9.7 ± 6.8 | e: 12.7 ± 6.3 f: 12.4 ± 6.01 | g: 6.7 ± 5.5 h: 4.1 ± 3.7 | < 0.0001 | ns | ns | ns |
IL-11 | a: 15.6 ± 8.3 b: 7.1 ± 6.2 | c: 13.4 ± 8.6 d: 11.3 ± 8.5 | e: 16.5 ± 8.3 f: 14.3 ± 8.2 | g: 8.3 ± 6.4 h: 5.5 ± 5.2 | < 0.0001 | ns | ns | 0.049 |
IL-17 | a: 9.8 ± 3.9 b: 4.3 ± 3.8 | c: 8.2 ± 4.8 d: 7.4 ± 4.6 | e: 10.2 ± 4.1 f: 9.4 ± 3.7 | g: 4.9 ± 4.01 h: 3.3 ± 3.6 | < 0.0001 | ns | ns | ns |
VEGF | a: 38.64 ± 10.8 b: 13.7 ± 6.9 | c: 33.5 ± 14 d: 27.9 ± 15.07 | e: 40.8 ± 8.5 f: 32.8 ± 14.3 | g: 23 ± 12.4 h: 14.05 ± 6.08 | < 0.0001 | 0.03 | 0.01 1.2 | 0.02 |
TGF-β | a: 15.2 ± 7.6 b: 7.5 ± 5.1 | c: 13.5 ± 7.9 d: 10.9 ± 7.3 | e: 16.4 ± 7.8 f: 13.6 ± 7.1 | g: 8.7 ± 5.3 h: 5.4 ± 4.2 | < 0.0001 | ns | ns | 0.039 |
Rb | a: 9.1 ± 5.7 b: 14.06 ± 6.4 | c: 10.7 ± 6.2 d: 11.1 ± 6.8 | e: 9.4 ± 6.1 f: 8.8 ± 5.4 | g: 13 ± 5.8 h: 15.8 ± 7.3 | 0.0006 | ns | ns | ns |
P53 | a: 10.4 ± 6.7 b: 13.9 ± 6.6 | c: 10.8 ± 6.3 d: 13 ± 7.4 | e: 10.1 ± 6.01 f: 10.9 ± 6.8 | g: 11.9 ± 5.6 h: 17.3 ± 6.9 | 0.04 | ns | ns | 0.02 |
ROS | a: 10.2 ± 9.7 b: 6.09 ± 5.3 | c: 8.9 ± 8.09 d: 9.07 ± 8.1 | e: 9.8 ± 10.44 f: 9.6 ± 10.11 | g: 5.2 ± 4.7 h: 7.5 ± 6.1 | 0.03 | ns | ns | ns |
RNS | a: 11.8 ± 10.3 b: 5.2 ± 5.3 | c: 9.6 ± 9.6 d: 9.2 ± 9.08 | e: 12.52 ± 10.57 f: 10.9 ± 10.1 | g: 5 ± 5.6 h: 5.3 ± 5.06 | 0.0002 | ns | ns | ns |
Survivin | a: 17.8 ± 4.8 b: 9 ± 6.2 | c: 16.3 ± 6.5 d: 12.3 ± 6.5 | e: 19.9 ± 3.3 f: 15.1 ± 5.1 | g: 10.4 ± 6.3 h: 6.5 ± 5.2 | < 0.0001 | 0.031 | 0.02 | ns |
Bcl-2 | a: 12.1 ± 4.2 b: 6.4 ± 4.5 | c: 11.4 ± 5.4 d: 8.2 ± 4 | e: 14.1 ± 3.9 f: 9.5 ± 3.5 | g: 17.6 ± 0.5 h: 5.7 ± 3.9 | 0/0001 | 0.033 | 0.008 | 0.0005 |
CD44 | a: 7.9 ± 5.1 b: 4.03 ± 2.4 | c: 8.6 ± 4.7 d: 3.5 ± 2.6 | e: 10.7 ± 4.7 f: 3.5 ± 1.6 | g: 5.3 ± 2.2 h: 3.5 ± 3.5 | 0.0003 | < 0.0001 | < 0.0001 | 0.004 |
TWIST | a: 10.2 ± 12.2 b: 6.4 ± 7.2 | c: 8.6 ± 10.5 d: 9.2 ± 11.3 | e: 9.9 ± 11.9 f: 10.7 ± 12.8 | g: 6.5 ± 7.4 h: 6.2 ± 7.01 | ns | ns | ns | ns |
E-cad | a: 12.9 ± 8.4 b: 13.5 ± 5.6 | c: 13.6 ± 7.7 d: 12.5 ± 7.3 | e: 13.3 ± 8.6 f: 12.4 ± 8.3 | g: 14.1 ± 6.2 h: 12.6 ± 4.7 | ns | ns | ns | ns |
N-cad | a: 10.7 ± 11.6 b: 5.8 ± 8.4 | c: 8.6 ± 10.5 d: 9.5 ± 11.4 | e: 10.2 ± 11.1 f: 11.4 ± 12.1 | g: 6 ± 8.8 h: 5.6 ± 8.1 | 0.009 | ns | ns | ns |
PTPN13 | a: 9.7 ± 5.9 b: 12.9 ± 6.6 | c: 10.8 ± 6.4 d: 11.03 ± 6.3 | e: 10.09 ± 6.22 f: 9.3 ± 5.7 | g: 12 ± 6.7 h: 14.5 ± 6.3 | 0.03 | ns | ns | ns |
SLUG | a: 2.1 ± 1.8 b: 1.1 ± 2.7 | c: 1.8 ± 2.04 d: 1.9 ± 2.3 | e: 2.05 ± 1.7 f: 2.6 ± 1.7 | g: 1.6 ± 2.4 h: 0.2 ± 3.02 | ns | ns | ns | ns |