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Fig. 7 | BMC Cancer

Fig. 7

From: Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression

Fig. 7

DNMT3B upregulation is responsible for the hypermethylation of the MYH11 promoter. A, the expression of DNMT3A and DNMT3B in GC was queried in StarBase Pan-cancer platform; B, the enrichment ability of DNMT3A and DNMT3B on MYH11 promoter examined by ChIP-qPCR; C, DNMT3B mRNA expression in GC tumor tissues and their adjacent tissues by RT-qPCR; D, correlation of DNMT3B expression with MYH11 promoter methylation levels in tumor tissues analyzed by Pearson’s correlation analysis (r = 0.623, p < 0.001); E, correlation of DNMT3B expression with MYH11 expression in tumor tissues (r = − 0.609, p < 0.001); F, transfection efficiency of oe-DNMT3B in GC cells by RT-qPCR; G, the effects of DNMT3B overexpression on the methylation level of MYH11 promoter examined by qMSP; H, effects of DNMT3B overexpression on MYH11 expression by RT-qPCR. Each assay was performed at least three times. Statistical significance was analyzed by paired t test (panel C) or two-way ANOVA (panels B, F, G and H) and Tukey’s multiple range tests

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