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Fig. 3 | BMC Cancer

Fig. 3

From: Gene-associated methylation status of ST14 as a predictor of survival and hormone receptor positivity in breast Cancer

Fig. 3

Differential gene expression and correlation analyses. a Volcano plot analyses for genes involved in matriptase-associated and epithelial-mesenchymal transition (EMT)-associated pathways in TCGA, GSE5364, and GSE22820 datasets. In these three datasets, XBP1 was significantly up-regulated with a high -log10P value in the high GAM status group (red). Conversely, PLAUR, FOXC2, and SNAI2 were significantly down-regulated with a high -log10P (blue). b Relative expression levels of the differentially expressed genes in the three datasets, with low GAM status as the referencing condition. c Correlation heatmap between CpG probes, matriptase-associated genes (left panel), and EMT-associated genes (right panel). The color bar for Pearson’s correlation coefficients is shown on the right. Genes and probes with higher correlation (abstract coefficient > 3) are colored in red. d Overall correlation between CpG probes, matriptase-associated genes (left panel), and EMT-associated genes (right panel)

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