Skip to main content

Table 4 Correlation of the percentage of TILs and the expression of the studied biomarkers among themselves. Correlations were calculated by Spearman’s test. Statistically significant associations are highlighted in bold. The ρ (rho) indicates the strength of the correlation and was classified as follows: ρ = 0.00 to 0.019 (very weak correlation), ρ = 0.20 to 0.39 (weak correlation), ρ = 0, 40 to 0.69 (moderate correlation), ρ = 0.70 to 0.89 (strong correlation), ρ = 0.90 to 1.00 (very strong correlation)

From: A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma

Markers

CD20

CD4

CD163

CD8

CD68

FOXP3

PD-L1 Stroma

PD-L1 Tumor

PD1

PTEN Absent

pSTAT1

TIL*

 ρ

0.227

0.143

0.214

0.209

0.163

−0.027

0.350

0.290

0.139

0.072

0.142

p-value

0.057

0.234

0.073

0.080

0.176

0.825

0.020

0.027

0.259

0.550

0.236

CD20

 ρ

 

0.049

0.010

−0.001

− 0.141

− 0.021

0.210

0.213

−0.105

0.010

−0.140

p-value

 

0.677

0.933

0.990

0.226

0.858

0.153

0.097

0.378

0.930

0.227

CD4

 ρ

  

0.419

0.658

0.791

0.52

0.130

0.0003

0.046

0.207

0.062

p-value

  

0.0002

< 0.0001

< 0.0001

< 0.0001

0.380

0.998

0.699

0.073

0.595

CD163

 ρ

   

0.263

0.544

0.310

0.459

0.234

0.169

0.410

0.070

p-value

   

0.022

< 0.0001

0.006

0.001

0.067

0.152

< 0.0001

0.551

CD8

 ρ

    

0.604

0.374

0.084

−0.041

−0.031

0.056

0.096

p-value

    

0.001

0.001

0.569

0.753

0.794

0.633

0.410

CD68

ρ

     

0.517

0.087

−0.061

0.087

0.249

0.029

p-value

     

< 0.0001

0.555

0.638

0.465

0.030

0.802

FOXP3

ρ

      

0.181

−0.278

0.033

0.281

0.174

p-value

      

0.218

0.029

0.780

0.014

0.133

PD-L1 Stroma

ρ

       

0.519

0.188

0.451

−0.087

p-value

       

< 0.0001

0.206

0.001

0.557

PD-L1 Tumor

ρ

        

0.110

0.187

−0.031

p-value

        

0.399

0.145

0.811

PD-1

ρ

         

0.042

−0.153

p-value

         

0.726

0.198

PTEN

ρ

          

0,004

p-value

          

0.972