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Table 8 Univariate and multivariate cox regression analysis of HECW1 expression classifier and clinical characteristics with overall survival and progression-free survival in the training cohort (n = 150) (1:1 ratio)

From: Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma

 

Overall survival

Progression-free survival

Characteristics

Univariate

Multivariate

Univariate

Multivariate

HR(95% CI)

P value

HR(95% CI)

P value

HR(95% CI)

P value

HR(95% CI)

P value

Age (≥60y vs < 60y)

1.550 (0.681–3.525)

0.296

  

1.251 (0.599–2.615)

0.551

  

Gender (Male vs Female)

0.995 (0.409–2.424)

0.992

  

0.958 (0.435–2.110)

0.915

  

WHO/ISUP Grading (III-IV vs I-II)

3.804 (1.645–8.795)

0.002

1.412 (0.595–3.352)

0.434

2.148 (1.032–4.469)

0.041

1.079 (0.499–2.333)

0.846

TNM stage (III-IV vs I-II)

5.843 (2.222–15.363)

< 0.001

3.028 (1.115–8.222)

0.03

9.042 (4.157–19.667)

< 0.001

5.441 (2.329–12.712)

< 0.001

SSIGN (≥5 vs 1–4)

9.235 (3.881–21.975)

< 0.001

2.635 (1.058–6.562)

0.037

17.907 (8.057–39.800)

< 0.001

7.604 (3.169–18.243)

< 0.001

HECW1 (High vs Low)

51.099 (6.841–381.667)

< 0.001

29.907 (3.750–238.530)

0.001

10.054 (4.183–26.373)

< 0.001

5.072 (1.728–14.891)

0.003

  1. SSIGN Stage, Size, Grade, and Necrosis, TNM Tumor Node Metastasis