Table 6 Univariate and multivariate cox regression analysis of HECW1 expression classifier and clinical characteristics with overall survival and progression-free survival in the training cohort (n = 180) (3:2ratio)

Age (≥60y vs < 60y)

1.061 (0.493–2.288)

0.879

0.664 (0.324–1.350)

0.664

Gender (Male vs Female)

0.558 (0.211–1.476)

0.24

1.154 (0.577–2.31)

0.686

WHO/ISUP Grading (III-IV vs I-II)

3.901 (1.813–8.394)

< 0.001

2.095 (0.889–4.938)

0.091

2.345 (1.205–4.561)

0.012

1.065 (0.521–2.177)

0.863

TNM stage (III-IV vs I-II)

11.791 (5.126–27.121)

< 0.001

3.797 (1.633–8.829)

0.002

9.999 (5.004–19.982)

< 0.001

4.504 (2.145–9.457)

< 0.001

SSIGN (≥5 vs 1–4)

10.030 (4.199–23.961)

< 0.001

3.872 (1.477–10.150)

0.006

19.698 (9.141–42.449)

< 0.001

7.815 (3.456–17.672)

< 0.001

HECW1 (High vs Low)

69 (9.253–514.551)

< 0.001

33.384 (4.218–264.224)

< 0.001

15.432 (5.919–40.233)

< 0.001

7.554 (2.602–21.930)

< 0.001