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Fig. 1 | BMC Cancer

Fig. 1

From: Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma

Fig. 1

HECW1 expression is decreased in clear cell renal cell carcinoma. (a), The protein expression of HECW1 in ccRCC samples was determined by Data-independent acquisition mass spectrometry (DIA-MS) assay. (b) The expression of HECW1 in ccRCC tissues (Tumor, n = 508) and normal adjacent tissues (Normal, n = 72) from The Cancer Genome Atlas (TCGA) datasets was analyzed. The normalized read counts are shown in boxplots to compare the expression differences. (c) The expression of HECW1 between ccRCC tumor tissues (n = 69) and normal adjacent tissues (n = 69) from TCGA datasets was analyzed the same way as described above. (d) Real-time PCR was used to detect the relative mRNA expression of HECW1 in tumor samples and their paired normal adjacent tissues from ccRCC patients (n = 60). (e) Representative images of hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) staining for HECW1 in ccRCC tissues and normal adjacent tissues are presented (scale bar = 20 μm). The expression of HECW1 evaluated by the H-score method (for details, see Materials and Methods) in corresponding tissues is shown, and the values are represented as the mean ± SD (***p < 0.001; Wilcoxon test)

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