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Table 4 Comparison of Prediction Score and other indicators in predicting the progression of advanced NSCLC

From: Predicting disease progression in advanced non-small cell lung cancer with circulating neutrophil-derived and platelet-derived microparticles

Variables Cutoff AUC 95% CI Sensitivity Specificity PPV NPV P
Prediction Score 16 0.825 (0.715,0.934) 80.8% 88.3% 75.0% 91.4% < 0.0001
total MPs, events/μL 2800 0.686 (0.559,0.813) 69.2% 68.3% 48.6% 83.7% 0.006
NMPs, events/μL 160 0.712 (0.598,0.827) 69.2% 65.0% 46.2% 83.0% 0.002
PMPs, events/μL 80 0.804 (0.706,0.903) 84.6% 68.3% 53.7% 91.1% < 0.0001
NLR 3.3 0.648 (0.513,0.784) 57.7% 78.3% 53.6% 81.0% 0.029
CEA, ng/ml 5.0 0.652 (0.515,0.788) 69.2% 65.0% 46.2% 83.0% 0.026
CYFRA21-1, ng/ml 2.5 0.741 (0.628,0.855) 96.2% 43.3% 42.4% 96.3% 0.058
LDH, U/L 210 0.694 (0.576,0.812) 46.2% 85.0% 57.1% 78.5% 0.004
  1. PPV Positive predictive value, NPV Negative predictive value, MPs microparticals, NMPs neutrophil-derived microparticals, PMPs platelet-derived microparticles, CEA carcino-embryonic antigen, CYFRA-211 Cytokeratin 19 fragment, NLR neutrophil-lymphocyte ratio, LDH lactate dehydrogenase, CEA carcino-embryonic antigen