Skip to main content

Table 1 Baseline variables and micropaticles in OR group and PD group of 86 cases of NSCLC

From: Predicting disease progression in advanced non-small cell lung cancer with circulating neutrophil-derived and platelet-derived microparticles

Variables OR (n = 60) PD (n = 26) P
Male, gender, n(%) 45 (75.0) 19 (73.1) 0.851*
Age, years, x ± s 61.8 ± 10.7 62.6 ± 11.1 0.760§
Current or former smokers, n(%) 31 (51.7) 17 (65.4) 0.239*
Histology, n(%)    0.297*
 Adenocarcinoma 25 (41.7) 14 (53.8)  
 Squamous carcinoma 35 (58.3) 12 (46.2)  
Disease stage, n(%)    0.274*
 Stage III 26 (43.3) 8 (30.8)  
 Stage IV 34 (56.7) 18 (69.2)  
Lines of therapy, n (%)    0.759*
 <2 21 (35.0) 10 (38.5)  
  ≥ 2 39 (65.0) 16 (61.5)  
Therapeutic intervention, n(%)    0.343*
 Chemotherapy+Immunotherapy 31 (51.7) 10 (38.5)  
 Chemotherapy 21 (35.0) 9 (34.6)  
 Immunotherapy 5 (8.3) 3 (11.5)  
 Target therapy 3 (5.0) 4 (15.4)  
No. of metastatic organs, n(%)    1.000*
 <2 30 (50.0) 13 (50.0)  
  ≥ 2 30 (50.0) 13 (50.0)  
No. of metastatic lymph nodes, n(%)    0.773*
 <2 18 (30.0) 7 (26.9)  
  ≥ 2 42 (70.0) 19 (73.1)  
KPS score, n(%)    0.733*
 90 54 (90.0) 22 (84.6)  
 80 4 (6.7) 2 (7.7)  
 70 2 (3.3) 2 (7.7)  
Laboratory indices at baseline, median(IQR)    
 Neutrophils, ×109/L 3.61 [2.70,4.50] 3.62 [2.87,4.63] 0.929#
 Platelets, ×109/L 205 [154,258] 200 [144,265] 0.914#
 NLR 3.32 [2.11,4.60] 3.27 [1.75,4.56] 0.803#
 LDH, U/L 191 [160,229] 188 [164,237] 0.566#
 CEA, ng/ml 5.10 [1.94,32.71] 5.23 [1.81,36.86] 0.925#
 CYFRA 21-1, ng/ml 5.14 [3.33,7.93] 5.50 [3.33,8.98] 0.413#
 SCC, ng/ml 1.10 [0.85,1.63] 1.08 [0.82,1.75] 0.745#
Micropaticals at baseline, events/μL, median(IQR)    
 total MPs 2632 [1942,3600] 2586 [1311,3490] 0.771#
 NMPs 164 [118,317] 217 [121,267] 0.836#
 PMPs 205 [154,258] 174 [143,211] 0.951#
  1. KPS Karnofsky’s index of performance status, NLR neutrophil-lymphocyte ratio, LDH lactate dehydrogenase, CEA carcino-embryonic antigen, CYFRA-211 Cytokeratin 19 fragment, SCC Squamous cell carcinoma antigen, MPs microparticals, NMPs neutrophil-derived microparticals, PMPs platelet-derived microparticles
  2. *Chi-square test
  3. §t test
  4. #Mann-Whitney U test