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Table 1 Baseline variables and micropaticles in OR group and PD group of 86 cases of NSCLC

From: Predicting disease progression in advanced non-small cell lung cancer with circulating neutrophil-derived and platelet-derived microparticles

Variables

OR (n = 60)

PD (n = 26)

P

Male, gender, n(%)

45 (75.0)

19 (73.1)

0.851*

Age, years, x ± s

61.8 ± 10.7

62.6 ± 11.1

0.760§

Current or former smokers, n(%)

31 (51.7)

17 (65.4)

0.239*

Histology, n(%)

  

0.297*

 Adenocarcinoma

25 (41.7)

14 (53.8)

 

 Squamous carcinoma

35 (58.3)

12 (46.2)

 

Disease stage, n(%)

  

0.274*

 Stage III

26 (43.3)

8 (30.8)

 

 Stage IV

34 (56.7)

18 (69.2)

 

Lines of therapy, n (%)

  

0.759*

 <2

21 (35.0)

10 (38.5)

 

  ≥ 2

39 (65.0)

16 (61.5)

 

Therapeutic intervention, n(%)

  

0.343*

 Chemotherapy+Immunotherapy

31 (51.7)

10 (38.5)

 

 Chemotherapy

21 (35.0)

9 (34.6)

 

 Immunotherapy

5 (8.3)

3 (11.5)

 

 Target therapy

3 (5.0)

4 (15.4)

 

No. of metastatic organs, n(%)

  

1.000*

 <2

30 (50.0)

13 (50.0)

 

  ≥ 2

30 (50.0)

13 (50.0)

 

No. of metastatic lymph nodes, n(%)

  

0.773*

 <2

18 (30.0)

7 (26.9)

 

  ≥ 2

42 (70.0)

19 (73.1)

 

KPS score, n(%)

  

0.733*

 90

54 (90.0)

22 (84.6)

 

 80

4 (6.7)

2 (7.7)

 

 70

2 (3.3)

2 (7.7)

 

Laboratory indices at baseline, median(IQR)

   

 Neutrophils, ×109/L

3.61 [2.70,4.50]

3.62 [2.87,4.63]

0.929#

 Platelets, ×109/L

205 [154,258]

200 [144,265]

0.914#

 NLR

3.32 [2.11,4.60]

3.27 [1.75,4.56]

0.803#

 LDH, U/L

191 [160,229]

188 [164,237]

0.566#

 CEA, ng/ml

5.10 [1.94,32.71]

5.23 [1.81,36.86]

0.925#

 CYFRA 21-1, ng/ml

5.14 [3.33,7.93]

5.50 [3.33,8.98]

0.413#

 SCC, ng/ml

1.10 [0.85,1.63]

1.08 [0.82,1.75]

0.745#

Micropaticals at baseline, events/μL, median(IQR)

   

 total MPs

2632 [1942,3600]

2586 [1311,3490]

0.771#

 NMPs

164 [118,317]

217 [121,267]

0.836#

 PMPs

205 [154,258]

174 [143,211]

0.951#

  1. KPS Karnofsky’s index of performance status, NLR neutrophil-lymphocyte ratio, LDH lactate dehydrogenase, CEA carcino-embryonic antigen, CYFRA-211 Cytokeratin 19 fragment, SCC Squamous cell carcinoma antigen, MPs microparticals, NMPs neutrophil-derived microparticals, PMPs platelet-derived microparticles
  2. *Chi-square test
  3. §t test
  4. #Mann-Whitney U test