Fig. 3

Association of biomarker stains and radioresistance was investigated across 23 cell lines. Bars represent estimated marginal means and error bars indicate 95% confidence intervals determined using bootstrapping. Sample sizes, F values and p values are indicated. A p53, B EGFR, and D CIP2A demonstrate no association with radioresistance, whereas C NDFIP1, and E Oct4 have a significant (*) association with the intrinsic radioresistance of the cell lines. F A highly significant interaction effect between p53 and Oct4 was revealed, implying a predictive role of Oct4 in the absence of p53 mutation/amplification type staining. G The interaction trend between p53 and EGFR did not reach significance