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Table 1 IC50 values of PDX and other agents

From: Characterization of newly established Pralatrexate-resistant cell lines and the mechanisms of resistance

 

IC50 (nM)

CEM

CEM/P

[ratio]

MOLT4

MOLT4/P

[ratio]

PDX

0.6

20

33

2.4

80

33

MTX

8.5

18

2.1

40

120

3.0

FDSa

4.2

1.6

0.4

8.0

7.0

0.9

AraC

30

35

1.2

24

2.0

0.1

BOR

3.7

6.5

1.8

5.9

6.5

1.1

LBH589

5.5

5.0

0.9

5.5

6.2

1.1

DAC

6.5 × 103

2.3 × 103

0.4

3.7 × 103

750

0.2

  1. IC50 50% growth inhibitory concentration, PDX pralatrexate, MTX methotrexate, FDS forodesine, AraC cytarabine, BOR bortezomib, LBH589 panobinostat, DAC 5-aza-2′-deoxycytidine
  2. aIn assays using FDS, cells were incubated with deoxyguanosine (10 μM) because the cytotoxicity of FDS requires the presence of deoxyguanosine in vitro
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BMC Cancer

ISSN: 1471-2407

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