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Table 1 Baseline characteristics and surgery rate according to dependent variables

From: Overtreatment in nonmalignant lesions detected in a colorectal cancer screening program: a retrospective cohort study

 

Patients not requiring surgery (n = 15,545)

Surgery (n = 162)

Surgery rate % (95% CI)

Significancea

Sex (n = 15,707)

• Female

6708 (43.2%)

72 (44.4%)

1.06 (0.82–1.31)

0.7

• Male

8837 (56.8%)

90 (55.6%)

1.01 (0.80–1.22)

Age (n = 15,707)

• < 60 years

6855 (44.1%)

48 (29.6%)

0.69 (0.50–0.89)

< 0.001

• ≥60 years

8690 (55.9%)

114 (70.4%)

1.29 (1.06–1.53)

PS (n = 15, 383)

• 0

12,388 (81.3%)

132 (83.0%)

1.05 (0.87–1.23)

0.8

• 1

2836 (18.6%)

27 (17.0%)

0.94 (0.59–1.29)

ASA (n = 15,383)

• I

8876 (58.2%)

96 (60.3%)

1.07 (0.86–1.28)

0.9

• II

5391 (35.4%)

53 (33.3%)

0.97(0.71–1.23)

• III

957 (6.3%)

10 (6.3%)

1.03 (0.40–1.67)

Fecal Hb (n = 15,707)

• < 100 μg/g

10,388 (66.8%)

79 (48.8%)

0.75 (0.59–0.92)

< 0.001

• 100–200 μg/g

2935 (18.9%)

41 (25.3%)

1.42 (0.99–1.86)

• > 200 μg/g

2222 (14.3%)

42 (25.9%)

1.85 (1.30–2.41)

N.colonoscopies (n = 15,707)

• One

13,557 (87.2%)

122 (75.3%)

0.89 (0.73–1.05)

< 0.001

• At least two

1988 (12.8%)

40 (24.7%)

1.97 (1.37–2.58)

Number of polyps (n = 15,707)

2 (IQR 1–4)

3 (IQR 1–5)

 

< 0.001

Number of adenomas (n = 15,707)

1 (IQR 0–3)

2 (IQR 1–4)

 

< 0.001

Adenoma size (mm) (n = 15,707)

5 (IQR 0–12)

19 (IQR 8–31.3)

 

< 0.001

European guidelines classification (n = 15,707)

• No adenoma

4650 (29.9%)

4 (2.5%)

0.08 (0.00–0.17)

< 0.001

• Low risk

3626 (23.3%)

4 (2.5%)

0.11 (0.00–0.22)

• Intermediate risk

4179 (26.9%)

17 (10.5%)

0.40 (0.21–0.59)

• High risk

3090 (19.9%)

137 (84.6%)

4.24 (3.55–4.94)

Endoscopist’s ADR (n = 15,459)

• Q1 (≤60%)

2653 (17.3%)

42 (26.1%)

1.56 (1.09–2.03)

0.02

• Q2 (60–65.3%)

3989 (26.1%)

40 (24.8%)

0.99 (0.67–1.30)

• Q3 (65.3–70.8%)

4181 (27.3%)

34 (21.1%)

0.81 (0.54–1.08)

• Q4 (> 70.8%)

4474 (29.2%)

45 (28.0%)

0.99 (0.71–1.28)

Endoscopist’s number of colonoscopies (n = 15,459)

• Q1 (≤57)

198 (1.3%)

2 (1.2%)

1.00 (−0.38–2.38)

0.03

• Q2 (58–278)

1647 (10.8%)

18 (11.2%)

1.08 (0.58–1.58)

• Q3 (279–507)

5340 (34.9%)

39 (24.2%)

0.72 (0.50–0.95)

• Q4 (> 507)

8113 (53.0%)

102 (63.4%)

1.24 (1.00–1.48)

Complexity of hospital (n = 15,707)

• Third level

7150 (46.0%)

52 (32.1%)

0.72 (0.53–0.92)

< 0.001

• Second level

8395 (54.0%)

110 (67.9%)

1.29 (1.05–1.53)

  1. ADR Adenoma detection rate, ASA American Society of Anesthesiologists’ Physical Status, CI Confidence interval, Hb Hemoglobin, IQR Interquartile range, PS Performance status
  2. aSignificance in the univariant analysis using the Chi-square test for qualitative variables and the Student’s t test for cuantitative variables