Table 2 Univariate and multivariate Cox regression analysis for predicting OS of PUC

 <70

Ref

Ref

 ≥ 70

1.906

1.667–2.179

<0.001^*

1.948

<0.001^*

 Male

Ref

 Female

0.919

0.803–1.051

0.281

 White

Ref

 Black

1.102

0.937–1.297

0.241

 Other

1.050

0.786–1.404

0.741

 I

Ref

Ref

 II

1.192

0.847–1.678

0.313

1.207

0.220

 III

1.407

1.014–1.953

0.041^*

1.156

0.334

 IV

1.342

0.961–1.874

0.085

1.214

0.213

 SCC

Ref

 TCC

1.122

0.957–1.314

0.155

0.899

0.251

 AC

0.906

0.737–1.114

0.301

0.765

0.014^*

 Other

1.289

1.037–1.601

0.022^*

0.898

0.352

 T0/T1

Ref

Ref

 T2

1.105

0.913–1.337

0.307

1.125

0.539

 T3

1.577

1.313–1.894

<0.001^*

1.444

0.020^*

 T4

2.144

1.738–2.646

<0.001^*

1.788

<0.001^*

 N0

Ref

Ref

 N1

1.530

1.239–1.891

<0.001^*

1.057

0.643

 N2

1.810

1.464–2.238

<0.001^*

1.413

0.014^*

 M0

Ref

Ref

 M1

4.646

3.845–5.615

<0.001^*

3.080

<0.001^*

 I

Ref

Ref

 II

1.075

0.859–1.345

0.528

1.015

0.947

 III

1.271

1.030–1.570

0.026^*

1.037

0.843

 IV

2.685

2.247–3.209

<0.001^*

0.973

0.891

 <30

Ref

Ref

 ≥ 30

1.662

1.307–2.115

<0.001^*

1.369

<0.001^*

 No surgery

Ref

Ref

 Local therapy

0.599

0.511–0.701

<0.001^*

0.832

0.037^*

 Radical therapy

0.458

0.389–0.539

<0.001^*

0.626

<0.001^*

 No/Unknown

Ref

 Yes

1.003

0.866–1.162

0.966

 No/Unknown

Ref

 Yes

0.984

0.855–1.134

0.826