Neo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial

Table 1 Pre-operative trial treatment schedule and dose

Drug or treatment	Dose and route	Frequency	Total number of treatments	Treatment period
Paclitaxel	80 mg/m² IV	Q1w	12	Week 1 until week 12
Doxorubicin	60 mg/m² IV	Q2w	4	Week 13 until week 19
Cyclophosphamide	600 mg/m² IV	Q2w	4	Week 13 until week 19
Radiation therapy to the primary breast cancer	8 Gy	Daily	3	Just before week 5
Durvalumab	1500 mg IV	Q4w	5	Week 1 until week 17
Oleclumab	3000 mg IV	Q2W for 5 administrations, then Q4W during 2 administrations	7	Week 1 until week 17

ISSN: 1471-2407