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Table 3 Clinicopathologic information about residual/persistent OSCCs

From: Salvage surgery for patients with residual/persistent diseases after improper or insufficient treatment of oral squamous cell carcinoma: can we rectify these mistakes?

Characteristics n (%) OS (%) p (Log-rank)
Residual subgroup
 MiRD group 26(25.2) 84.6 0.005
 MaRD group 54(52.4) 48.1
 RRD group 23(22.3) 65.2
Residual OSCC location
 Local 79(76.7) 60.8 0.950
 Regional 12(11.7) 66.7
 Locoregional 12(11.7) 58.3
Size of rOSCC*
 Minimal residual 21(20.4) 81.0 < 0.001
  ≤ 2 cm 35(34.0) 71.4
 2-4 cm 34(33.0) 55.9
  > 4 cm 13(12.7) 15.4
rOSCC involving vital structures#
 Yes 13(12.6) 38.5 0.049
 No 90(87.4) 64.4
Differentiation for rOSCC
 Well differentiated 9(8.7) 66.7 0.857
 Moderately differentiated 60(58.3) 61.7
 Poorly differentiated 34(33.0) 58.8
Pathological upgrade for rOSCC
 Yes 23(22.3) 69.6 0.583
 No 80(77.7) 58.8
Neurovascular invasion for rOSCC
 Yes 20(19.4) 70.0 0.583
 No 83(80.6) 59.0
Bone invasion for rOSCC
 Yes 31(30.1) 45.2 0.023
 No 72(70.0) 70.0
Margin status after salvage surgery
 Positive 4(3.9) 0.0 < 0.001
 Negative 99(96.1) 63.6
Complication after salvage surgery
 Yes 37(35.9) 56.8 0.488
 No 66(64.1) 63.6
Detailed complications
 Wound dehiscence or infection 14(37.8) 57.1 0.436
 Flap crisis or failure 4(10.8) 25.0
 Lung infection 12(32.4) 58.3
 Chyle leak 1(2.7) 100.0
 Deep venous thrombosis 2(5.4) 100.0
 Hematoma 1(2.7) 100.0
 Others 3(8.1) 33.3
Salvage treatment combinations
 Upfront salvage surgery 85(82.5) 64.7 0.033
 Adjuvant therapy followed by salvage surgery 18(17.5) 44.4
Salvage resection and reconstruction
 Simple resection with direct closure or local flap 19(18.4) 89.5 0.001
 Radical resection with free flap or PMMF coverage 58(56.3) 62.1
 Craniofacial surgery, total glossectomy, etc 26(25.2) 38.5
Adjuvant therapy
 Radiotherapy 43(51.2) 58.1 0.156
 Chemoradiation 25(29.8) 60.0
 Radiotherapy with targeted therapy 10(11.9) 50.0
 Chemoradiation with targeted therapy 6(7.1) 33.3
 None 19(18.4) 84.2
  1. * Sizes of residual OSCCs (rOSCC) were determined by pathological reports, with minimal residual lesions signifying lesions smaller than 1 cm
  2. #: Vital structures: Carotid artery, skull base or higher, glottic, hypopharynx, larynx