Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Table 9 Geospatiotemporal regression models

Parameter			Model
Parameter	Estimate (C.I.)	P-Value	LogLik	S.D.	Model Parameter	Estimate	P-Value
*Cannabis Alone*
*spreml (ALL_Rate ~ Cannabis)*
Cannabis	0.22 (0.09, 0.36)	0.0015	− 193.8962	0.4040	phi	0.5060	0.0005
*Additive Model*
*spreml (ALL_Rate ~ Cigarettes + Cannabis + AUD + Analgesics + Cocaine)*
Cannabis	0.16 (0.06, 0.27)	0.0032	N/A	0.3869	phi	0.4604	0.0005
					rho	−0.3274	0.0229
*Interactive Models - Drugs*
**spreml (ALL_Rate ~ Cigarettes Cannabis * AUD + Analgesics + Cocaine)***
Cigarettes: Cannabis: AUD	22.02 (10.13, 33.91)	0.0003	−189.4824	0.3760	phi	0.3669	0.0022
Cigarettes: AUD	45.76 (17.83, 73.69)	0.0013			rho	−0.3098	0.0349
Cannabis: AUD	−2.39 (−4.75, −0.02)	0.0482			lambda	0.2865	0.0162
*Interactive Models - Drugs, Income, Ethnicity*
**spreml (ALL_Rate ~ Cigarettes Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)***
Hispanic	0.21 (0.15, 0.26)	8.3E-13	−170.6536	N/A	rho	0.3314	0.0007
Asian	0.12 (0.04, 0.2)	0.0035			lambda	−0.3523	0.0011
Income	−0.29 (− 0.57, − 0.01)	0.0404
African-Am.	− 0.16 (− 0.21, − 0.12)	6.2E-14
*Interactive Cannabinoid Models - Drugs, Income, Ethnicity*
**spreml (ALL_Rate ~ Cigarettes THC * CBG + AUD + Analgesics + Cocaine + Income + 5_Races)***
Hispanic	0.23 (0.17, 0.28)	9.9E-15	− 163.7442	0.3325	phi	0.0495	0.1403
Cannabigerol	0.26 (0.01, 0.52)	0.0444			psi	0.0573	0.2640
Cigarettes: THC: Cannabigerol	−1.18 (−1.87, −0.49)	0.0008			rho	0.1791	0.2751
Cigarettes: THC	−4.96 (−7.8, −2.12)	0.0006			lambda	−0.2047	0.2159
African-Am.	−0.13 (− 0.18, − 0.09)	3.4E-09

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