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Table 6 Panel regression models

From: Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Parameters Model
Instrumental Variables Parameter Estimate (C.I.) P-Value Adj. R-Squared Chi Squared F dF P
  Additive Model        
  plm (ALL_Rate ~ Cigarettes + Cannabis + AUD + Analgesics + Cocaine + Income + 5_Races)
  Hispanic 0.2 (0.12, 0.27) 5.7E-07 0.1337   −55.3956 6503 1.0000
  Cannabis −0.22 (−0.33, − 0.11) 1.0E-04      
  Cigarettes −1.76 (−2.56, −0.96) 2.0E-05      
  Analgesics −12.01 (− 16.6, − 7.43) 4.0E-07      
  Black −0.13 (− 0.18, − 0.09) 3.7E-08      
  AUD −8.02 (−8.89, −7.15) <  2.2E-16      
  Interactive Model      
  plm (ALL_Rate ~ Cigarettes * Cannabis * AUD + Analgesics + Cocaine + Income + 5_Races)
  Cigarettes: AUD 1157.78 (876.06, 1439.5) 5.9E-15 0.0848   −29.2033 10,499 1.0000
  AIAN 5.35 (3.79, 6.9) 4.4E-11      
  Cigarettes: Cannabis: AUD 416.5 (291.07, 541.94) 1.9E-10      
  Cannabis 5.52 (3.71, 7.34) 4.7E-09      
  Cocaine 10.32 (3.78, 16.86) 0.0021      
  Analgesics −7.98 (−12.56, −3.41) 0.0007      
  Cannabis: AUD −87.24 (−115.7, −58.77) 3.7E-09      
  Cigarettes: Cannabis −28.11 (−36.54, −19.68) 1.6E-10      
  AUD − 236.82 (− 295.84, − 177.8) 2.3E-14      
  Cigarettes −83.55 (−103.35, −63.75) 1.2E-15      
  Interactive Cannabinoids      
  plm (ALL_Rate ~ Cigarettes + THC * Cannabigerol + AUD + Analgesics + Cocaine + Income + 5_Races)
  Cannabigerol 1.21 (0.86, 1.56) 1.4E-11 0.0359 −320.949   8 1
  Cocaine 6.84 (3.91, 9.78) 5.0E-06      
  Hispanic 0.18 (0.08, 0.28) 0.0003      
  Asian −0.13 (− 0.26, − 0.01) 0.0392      
  Analgesics −13.67 (− 18.79, −8.54) 1.7E-07      
  THC: Cannabigerol −0.61 (− 0.73, − 0.49) <  2.2E-16      
  Cigarettes −4.89 (−5.71, − 4.08) <  2.2E-16      
  THC −3.21 (−3.73, −2.69) <  2.2E-16      
  Additive Model      
  plm (ALL_Rate ~ Cigarettes + Cannabis + AUD + Analgesics + Cocaine + Income + 5_Races)
Cauc-Am._THC Exposure Hispanic-American 0.18 (0.13, 0.23) 2.6E-11 0.3279 254.327   6 2.6E-11
Afric-Am._THC Exposure Asian-American 0.1 (0.02, 0.18) 0.0126      
Hispan-Am._THC Exposure Cannabis 0.12 (0, 0.23) 0.0462      
Asian-Am._THC Exposure Analgesics −3.72 (−7.32, −0.12) 0.0431      
Income − 0.42 (− 0.7, − 0.14) 0.0037      
African-American −0.13 (− 0.17, − 0.09) 1.7E-12