Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Table 4 Linear regression models

Parameter	Parameter		Model Parameters
Parameter	Estimate (C.I.)	P-Value	SD	R-Squared	F	dF	P
*lm (ALL_Rate ~ Cannabis)*
Cannabis	0.3 (0.18, 0.41)	4.3E-07	4.06E-01	0.4728	26.26	1508	4.2E-07
*lm (ALL_Rate ~ Time)*
Year	0.01 (0, 0.01)	0.1670	4.06E-01	0.0018	1.916	1508	0.1670
**lm (ALL_Rate ~ Time Cannabis)***
Year	0.04 (−0.18, −0.02)	0.0130	0.4039	0.05638	11.14	3506	4.3E-07
Cannabis	30.51 (13.22, 132.81)	0.0171
Year: Cannabis	−0.02 (−0.07, − 0.01)	0.0176
*Additive model*
*lm (ALL_Rate ~ Cigarettes + AUD + Cannabis + Analgesics + Cocaine)*
cigmon	−3.3 (− 4.19, −2.41)	1.3E-12	0.382	0.1561	32.38	3506	< 2.2E-16
AUD	7.58 (5.17, 9.99)	1.5E-09
Cannabis	0.14 (0.03, 0.26)	0.0154
*Quintiles*
*lm (ALL_Rate ~ Quintile)*
Quintile 4	0.18 (0.07, 0.29)	0.0020	0.4071	0.0234	4.047	4505	0.0031
Quintile 5	0.19 (0.06, 0.32)	0.0037
**lm (ALL_Rate ~ Year Quintile)***
Year	0.03 (0.01, 0.05)	0.0061	0.4071	0.0416	3.456	9500	0.0004
Quintile 3	79.2 (26.91, 131.49)	0.0031
Quintile 4	74.23 (21.02, 127.44)	0.0065
Quintile 5	61.55 (3.2, 119.9)	0.0392
Year: Quintile 3	−0.04 (− 0.07, − 0.01)	0.0032
Year: Quintile 4	− 0.04 (− 0.06, − 0.01)	0.0066
Year: Quintile 5	− 0.03 (− 0.06, 0)	0.0397
**lm (ALL_Rate ~ Year Quintiles_Dichotomized)***
Upper Quintiles	0.15 (0.07, 0.22)	0.0001	0.4102	0.0272	15.24	1508	0.0001

ISSN: 1471-2407