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Table 12 Linear models from imputed data

From: Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Parameters Model
Parameter Estimate (C.I.) P-Value No. Imputa- tions SD lambda FMI
Cannabis Alone
lm (ALL_Rate ~ Ethnic_THC_Exposure
  Ethnic_THC_Exposure 0.14 (0.12, 0.17) 3.4E-26 60 0.2891 0.0562 0.0583
Additive Model
lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine)
  Ethnic_THC_Exposure 0.53 (0.44, 0.61) 6.2E-31 60 0.8246 0.0301 0.0321
  AUD 9.1 (5.3, 12.89) 3.1E-06    0.0301 0.0321
  Cigarettes 1.52 (0.09, 2.95) 0.0371    0.0294 0.0314
Interactive Model
lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis)
  Ethnic_THC_Exposure 0.42 (0.35, 0.5) 1.7E-27 60 0.8347 0.0335 0.0355
  Cocaine 10.69 (2.47, 18.92) 0.0110    0.0323 0.0343
Interactive Model with Cannabinoids
lm (ALLRate ~ Cigarettes + AUD + THC + Cannabigerol + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis)
  Cigarettes: Ethnic_THC_Exposure 3.77 (3.12, 4.42) 5.8E-13 60 0.6885 0.0270 0.0290
  Cannabigerol 2.14 (1.65, 2.63) 2.1E-17    0.0484 0.0505
  AUD: Ethnic_THC_Exposure 6.98 (5.08, 8.88) 1.2E-12    0.0251 0.0270
  Cigarettes −5.68 (−7.03, −4.33) 4.4E-16    0.0596 0.0617
  THC: Cannabigerol −19.56 (−22.57, − 16.55) 1.0E-34    0.0405 0.0425
  THC −2.63 (−3.03, − 2.23) 1.3E-35    0.0538 0.0559
Interactive Model with Ethnicity & Income
lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis + Income + NHWhite + NHAfrican-Am.)
  Ethnic_THC_Exposure 0.64 (0.55, 0.72) 3.1E-40 60 0.8028 0.0352 0.0373
  Cigarettes: AUD 27.3 (14.38, 40.22) 3.7E-05    0.0328 0.0348
  Analgesics −8.83 (−14.57, − 3.09) 0.0027    0.0268 0.0288
  Income −1.73E-05 (−2.46E-05, − 1.0E-05 3.7E-06    0.0482 0.0502
  Black −1.56 (−2.18, −0.94) 1.1E-06    0.0371 0.0391
  White −1.28 (− 1.72, −0.84) 2.6E-08    0.0313 0.0333
Interactive Model with Intensity Cannabis Use
  Cigarettes: Ethnic_THC_Exposure 2.97 (2.61, 3.32) 4.80E-53 60 0.7883 0.0206 0.0226
  Cigarettes: AUD −31.33 (−44.5, −18.17) 3.53E-06    0.0434 0.0455
  NHWhite_Cannabis_Intensity −1.32 (− 1.55, − 1.09) 6.34E-28    0.0420 0.0440
Interactive Model with Ethnicity & Income with Intensity Cannabis Use     
  lm (ALLRate ~ Cigarettes + AUD + Ethnic_Intensity_Cannabis_Use_Indices + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis + Income + NHWhite + NHAfrican-Am.)
  Cigarettes: Ethnic_THC_Exposure 4.69 (3.77, 5.61) 1.0E-22 60 0.7585 0.0231 0.0251
  Cigarettes: AUD 150 (67.09, 232.91) 4.0E-04    0.0479 0.0500
  Cocaine − 11.7 (−21.38, −2.02) 0.0181    0.0447 0.0467
  Income −1.1E-05 (−2.0E-05, −3.0E-06) 0.0097    0.0458 0.0478
  AUD: Ethnic_THC_Exposure −3.51 (−6.14, −0.88) 0.0088    0.0274 0.0294
  AUD −29.6 (−49.98, −9.22) 0.0045    0.0477 0.0497
  White −0.88 (−1.34, − 0.41) 0.0002    0.0441 0.0462
  Analgesics −11.6 (− 17.11, −6.09) 3.8E-05    0.0316 0.0336
  Cigarettes −17 (−22.66, − 11.34) 5.1E-09    0.0394 0.0415
  NHWhite_Cannabis_Intensity −1.58 (− 1.82, − 1.34) 4.2E-35    0.0472 0.0493