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Table 12 Linear models from imputed data

From: Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

Parameters

Model

Parameter

Estimate (C.I.)

P-Value

No. Imputa- tions

SD

lambda

FMI

Cannabis Alone

 lm (ALL_Rate ~ Ethnic_THC_Exposure

  Ethnic_THC_Exposure

0.14 (0.12, 0.17)

3.4E-26

60

0.2891

0.0562

0.0583

Additive Model

 lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine)

  Ethnic_THC_Exposure

0.53 (0.44, 0.61)

6.2E-31

60

0.8246

0.0301

0.0321

  AUD

9.1 (5.3, 12.89)

3.1E-06

  

0.0301

0.0321

  Cigarettes

1.52 (0.09, 2.95)

0.0371

  

0.0294

0.0314

Interactive Model

 lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis)

  Ethnic_THC_Exposure

0.42 (0.35, 0.5)

1.7E-27

60

0.8347

0.0335

0.0355

  Cocaine

10.69 (2.47, 18.92)

0.0110

  

0.0323

0.0343

Interactive Model with Cannabinoids

 lm (ALLRate ~ Cigarettes + AUD + THC + Cannabigerol + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis)

  Cigarettes: Ethnic_THC_Exposure

3.77 (3.12, 4.42)

5.8E-13

60

0.6885

0.0270

0.0290

  Cannabigerol

2.14 (1.65, 2.63)

2.1E-17

  

0.0484

0.0505

  AUD: Ethnic_THC_Exposure

6.98 (5.08, 8.88)

1.2E-12

  

0.0251

0.0270

  Cigarettes

−5.68 (−7.03, −4.33)

4.4E-16

  

0.0596

0.0617

  THC: Cannabigerol

−19.56 (−22.57, − 16.55)

1.0E-34

  

0.0405

0.0425

  THC

−2.63 (−3.03, − 2.23)

1.3E-35

  

0.0538

0.0559

Interactive Model with Ethnicity & Income

 lm (ALLRate ~ Cigarettes + AUD + Ethic_THC_Exposure + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis + Income + NHWhite + NHAfrican-Am.)

  Ethnic_THC_Exposure

0.64 (0.55, 0.72)

3.1E-40

60

0.8028

0.0352

0.0373

  Cigarettes: AUD

27.3 (14.38, 40.22)

3.7E-05

  

0.0328

0.0348

  Analgesics

−8.83 (−14.57, − 3.09)

0.0027

  

0.0268

0.0288

  Income

−1.73E-05 (−2.46E-05, − 1.0E-05

3.7E-06

  

0.0482

0.0502

  Black

−1.56 (−2.18, −0.94)

1.1E-06

  

0.0371

0.0391

  White

−1.28 (− 1.72, −0.84)

2.6E-08

  

0.0313

0.0333

 Interactive Model with Intensity Cannabis Use

  Cigarettes: Ethnic_THC_Exposure

2.97 (2.61, 3.32)

4.80E-53

60

0.7883

0.0206

0.0226

  Cigarettes: AUD

−31.33 (−44.5, −18.17)

3.53E-06

  

0.0434

0.0455

  NHWhite_Cannabis_Intensity

−1.32 (− 1.55, − 1.09)

6.34E-28

  

0.0420

0.0440

Interactive Model with Ethnicity & Income with Intensity Cannabis Use

    

  lm (ALLRate ~ Cigarettes + AUD + Ethnic_Intensity_Cannabis_Use_Indices + Analgesics + Cocaine + Cigarettes: AUD + Cigarettes: Ethnic_Cannabis + AUD: Ethnic_Cannabis + Income + NHWhite + NHAfrican-Am.)

  Cigarettes: Ethnic_THC_Exposure

4.69 (3.77, 5.61)

1.0E-22

60

0.7585

0.0231

0.0251

  Cigarettes: AUD

150 (67.09, 232.91)

4.0E-04

  

0.0479

0.0500

  Cocaine

− 11.7 (−21.38, −2.02)

0.0181

  

0.0447

0.0467

  Income

−1.1E-05 (−2.0E-05, −3.0E-06)

0.0097

  

0.0458

0.0478

  AUD: Ethnic_THC_Exposure

−3.51 (−6.14, −0.88)

0.0088

  

0.0274

0.0294

  AUD

−29.6 (−49.98, −9.22)

0.0045

  

0.0477

0.0497

  White

−0.88 (−1.34, − 0.41)

0.0002

  

0.0441

0.0462

  Analgesics

−11.6 (− 17.11, −6.09)

3.8E-05

  

0.0316

0.0336

  Cigarettes

−17 (−22.66, − 11.34)

5.1E-09

  

0.0394

0.0415

  NHWhite_Cannabis_Intensity

−1.58 (− 1.82, − 1.34)

4.2E-35

  

0.0472

0.0493