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Table 2 Treatment emergent adverse events occurring in ≥5% of patients

From: A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

Adverse event term All Grades Grade 1 or 2 Grade 3 or 4
Patients % patients (N = 47) Patients % patients (N = 47) Number of cycles % cycles (N = 194) Patients % patients (N = 47) Number of cycles % cycles (N = 194)
Blood and lymphatic system
 Anaemia 21 45% 15 32% 38 20% 6 13% 11 6%
 Febrile Neutropenia 4 9% 0 0% 0 0% 4 9% 5 3%
Gastrointestinal disorders
 Abdominal Pain 10 21% 10 21% 15 8% 0 0% 0 0%
 Diarrhoea 10 21% 8 17% 21 11% 2 4% 2 1%
 Dyspepsia 3 6% 3 6% 3 2% 0 0% 0 0%
 Mouth ulcer 3 6% 3 6% 4 2% 0 0% 0 0%
 Nausea 24 51% 24 51% 42 22% 0 0% 0 0%
 Vomiting 14 30% 14 30% 26 13% 0 0% 0 0%
General disorders
 Fatigue 22 47% 18 38% 53 27% 4 9% 4 2%
 Fever 4 9% 4 9% 4 2% 0 0% 0 0%
 Flu-like Symptoms 6 13% 6 13% 9 5% 0 0% 0 0%
Infections and infestations
 Bronchial Infection 4 9% 2 4% 7 4% 2 4% 2 1%
 Lung infection 7 15% 4 9% 6 3% 3 6% 3 2%
 Rhinitis infective 5 11% 5 11% 6 3% 0 0% 0 0%
 UTI 7 15% 6 13% 7 4% 1 2% 1 1%
Investigations
 ECG QTc interval prolonged 16 34% 14 30% 26 13% 2 4% 2 1%
 Neutropenia 22 47% 7 15% 37 19% 15 32% 28 14%
 Thrombocytopenia 18 38% 10 21% 53 27% 8 17% 20 10%
Metabolism and nutritional disorders
 Anorexia 13 48% 13 28% 24 12% 0 0% 0 0%
 Hypoalbuminemia 4 9% 4 9% 5 3% 0 0% 0 0%
 Hypokalaemia 5 11% 5 11% 5 3% 1 2% 1 1%
 Hypophosphatemia 3 6% 3 6% 4 2% 0 0% 0 0%
MSK and connective tissue
 Back Pain 3 6% 3 6% 3 2% 0 0% 0 0%
 Muscle cramps 3 6% 3 6% 3 2% 0 0% 0 0%
 Pain in extremity 4 9% 4 9% 4 2% 0 0% 0 0%
Nervous system disorders
 Headache 10 21% 8 17% 12 6% 0 0% 0 0%
Psychiatric disorders
 Depression 3 6% 2 4% 2 1% 0 0% 0 0%
Respiratory and thoracic disorders
 Cough 3 6% 3 6% 3 2% 0 0% 0 0%
 Dyspnoea 4 9% 4 9% 6 3% 0 0% 0 0%
  1. Adverse Events categorised and graded according to CTCAE v 4.03
  2. CTCAE National Cancer Institute Common Terminology for Adverse Events, ECG QTc electrocardiogram corrected QT interval, MSK musculoskeletal, UTI urinary tract infection