Table 2 Up- and down-regulated proteins identified by proteomic analysis and MS in ICC compared to control
Acc. n° UniProtKB | SPOT ID | Protein name | Pathway | Fold Change | Sequence coverage (%) | Number of Unique Peptides (C.I. 95%) |
|---|---|---|---|---|---|---|
Upregulated proteins | ||||||
 sp|P07108|ACBP_HUMAN | 4160 | Acyl-CoA-binding protein | Metabolism (lipids) | 14.3 | 72.4 | 7 |
 sp|P68871|HBB_HUMAN | 4079 | Hemoglobin subunit beta | Oxygen transport | 14.9 | 89.8 | 18 |
 sp|P68871|HBB_HUMAN | 4107 | Hemoglobin subunit beta | Oxygen transport | 14.4 | 89.8 | 18 |
 sp|P04040|CATA_HUMAN | 5348 | Catalase | Redox homeostasis | 10.6 | 21.3 | 6 |
 sp|Q03154|ACY1_HUMAN | 5189 | Aminoacylase-1 | Metabolism (amino acids) | 7.1 | 47.3 | 11 |
 sp|P47985|UCRI_HUMAN | 4383 | Cytochrome b-c1 complex subunit Rieske, mitochondrial | Metabolism | 5.6 | 20.8 | 4 |
 sp|P63261|ACTG_HUMAN | 4219 | Actin, cytoplasmic 2 | Cytoskeleton | 4.8 | 29.1 | 5 |
 sp|P30041|PRDX6_HUMAN | 4985 | Peroxiredoxin-6 | Redox homeostasis | 3.7 | 64.7 | 10 |
 sp|P32119|PRDX2_HUMAN | 4241 | Peroxiredoxin-2 | Redox homeostasis | 3.7 | 36.4 | 8 |
 sp|Q96IU4|ABHEB_HUMAN | 4989 | Protein ABHD14B | Cytosolic sulfonation of small molecules | 3.7 | 47.1 | 5 |
 sp|P04179|SODM_HUMAN | 4373 | Superoxide dismutase [Mn], mitochondrial | Redox homeostasis | 3.5 | 39.2 | 6 |
 sp|P62805|H4_HUMAN | 4118 | Histone H4 | DNA binding | 3.0 | 17.5 | 2 |
 sp|P00352|AL1A1_HUMAN | 5379 | Retinal dehydrogenase 1 | Cell signaling | 3.0 | 24 | 8 |
Downregulated proteins | ||||||
 sp|P54868|HMCS2_HUMAN | 5246 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | Metabolism | 0.45 | 29.9 | 6 |
 sp|P07237|PDIA1_HUMAN | 4842 | Protein disulfide-isomerase | Metabolism | 0.33 | 32.5 | 9 |
 sp|O95954|FTCD_HUMAN | 5113 | Formimidoyltransferase-cyclodeaminase | Metabolism | 0.29 | 39.7 | 8 |
 sp|P38646|GRP75_HUMAN | 5229 | Stress-70 protein, mitochondrial | Heat shock response | 0.23 | 15.5 | 7 |
 sp|P68363|TBA1B_HUMAN | 4835 | Tubulin alpha-1B chain | Cytoskeleton | 0.22 | 26.8 | 7 |
 sp|P06753|TPM3_HUMAN | 4302 | Tropomyosin alpha-3 chain | Cytoskeleton | 0.18 | 27.4 | 5 |