Table 4 MiRNAs and experimentally validated target genes involved in the Integrated Breast Cancer Pathway (Wikipathways) and their involvement in the clinical groups of this study
miRNAs | Experimentally validated targets | Clinical groups |
|---|---|---|
miR-1268a | CDC25B, MAPK1, RAP1A | LN status |
miR-1268b | CDC25B, MAPK1, RAP1A | LN status |
miR-130a-3p | ESR1, MYC, PTEN, SMAD4, TGFBR2 | REC status |
miR-184 | AKT1, BCL2, MYC | REC status |
miR-18a-5p | ATM, BCL2, CCND1, ESR1, PTEN, RAP1A, SMAD2, SMAD4, TFGBR2, TP53 | REC status |
miR-18b-5p | ESR1, MDM2, SMAD2 | REC status |
miR-200c-5p | CDH1, MDM2, PTEN | LN status |
miR-449-5p | CDC25A, FOSL1, HDAC1, SIRT1, SMAD4, TGFBR2 | REC status |
miR-452-5p | BMPR2, IRS1, KRAS, SMAD4 | Tumor size |
miR-519a-3p | PTEN, RB1 | REC status |
miR-99b-5p | CHEK1, MTOR, SP1 | REC status |